dibenzo[b,f]-1,4-thiazepine

Base Information

• Chemical Name: dibenzo[b,f]-1,4-thiazepine
• CAS No.: 257-15-8
• Molecular Formula: C₁₃H₉NS
• Molecular Weight: 211.287
• Mol file: 257-15-8.mol

Synonyms:dibenzo[b,f]-1,4-thiazepine

Chemical Property of dibenzo[b,f]-1,4-thiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzo[b,f]-1,4-thiazepine

There total 4 articles about dibenzo[b,f]-1,4-thiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(2-bromophenyl)-2-oxoacetic acid (26767-16-8) + 2-amino-benzenethiol (137-07-5) → dibenzo[b,f][1,4]thiazepin-11-one (3159-07-7) + dibenzo[b,f]-1,4-thiazepine (257-15-8)

Guidance literature:

With copper(l) iodide; caesium carbonate; L-proline; In N,N-dimethyl acetamide; at 110 ℃; for 12h; Sealed tube;

DOI:10.1021/acs.joc.1c02110

Reference yield: 43.0%

9H-thioxanthen-9-ol (6783-74-0) → thio-xanthene-9-one (492-22-8) + dibenzo[b,f]-1,4-thiazepine (257-15-8)

Guidance literature:

With mesitylenesulfonylhydroxylamine; In dichloromethane; at 20 ℃;

DOI:10.1002/hc.20010

Reference yield: 34.0%

N-[(2-Benzylthio)benzylidene]aniline → 2,2 dithiobis(benzonitrile) (33174-74-2) + benzoisothiazole (272-16-2) + 1,1'-(1,2-ethanediyl)bisbenzene (103-29-7) + dibenzo[b,f]-1,4-thiazepine (257-15-8)

Guidance literature:

at 650 ℃; for 0.25h; under 0.005 Torr; Further byproducts.;

DOI:10.1039/b009844m

upstream raw materials:

9H-thioxanthen-9-ol

Quetiapine

2-(2-bromophenyl)-2-oxoacetic acid

2-amino-benzenethiol

Downstream raw materials:

[3-(11H-dibenzo[b,f][1,4]thiazepin-10-yl)-propyl]-dimethyl-amine

thio-xanthene-9-one

Refernces

• 1、 Laha, Joydev K.,Hunjan, Mandeep Kaur. "Diversity in Heterocycle Synthesis Using α-Iminocarboxylic Acids: Decarboxylation Dichotomy". . p. 2315 - 2323. Retrieved 2022/02/07.
• 2、 Fujii, Takayoshi,Hao, Wei,Yoshimura, Toshiaki. "New method for the preparation of dibenzo[b,f][1,4]thiazepines". . p. 246 - 250. Retrieved 2007/10/03.