N,3-diphenylbutanamide

Base Information

• Chemical Name: N,3-diphenylbutanamide
• CAS No.: 74973-27-6
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.317
• Mol file: 74973-27-6.mol

Synonyms:N,3-diphenylbutanamide

Chemical Property of N,3-diphenylbutanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,3-diphenylbutanamide

There total 10 articles about N,3-diphenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(E)-crotonanilide (17645-30-6) + phenyllithium (591-51-5) → N,3-diphenylbutanamide (74973-27-6)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1016/S0040-4039(00)92805-3

Reference yield: 43.0%

crotonanilide (1733-40-0) + phenylmagnesium bromide → N,3-diphenylbutanamide (74973-27-6)

Guidance literature:

With methyllithium; In tetrahydrofuran; diethyl ether; at 20 ℃; for 3h;

DOI:10.1246/cl.2007.736

Reference yield: 39.0%

carbon monoxide (201230-82-2) + aniline (62-53-3) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → N,3-diphenylbutanamide (74973-27-6)

Guidance literature:

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; palladium dichloride; In tetrahydrofuran; water; at 110 ℃; for 24h; under 34202.3 Torr; Reagent/catalyst; regioselective reaction; Autoclave;

DOI:10.1021/jacs.1c03454

upstream raw materials:

(E)-crotonanilide

phenyllithium

crotonanilide

(E)-β-methylcinnamaldehyde

Downstream raw materials:

2-Chloro-3-(1-phenyl-ethyl)-quinoline

Dimethyl-{2-[3-(1-phenyl-ethyl)-quinolin-2-ylsulfanyl]-ethyl}-amine

Refernces

• 1、 Yuan, Pengfei,Chen, Jiean,Zhao, Jing,Huang, Yong. "Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species". supporting information. p. 8503 - 8507. Retrieved 2018/07/14.
• 2、 Baldwin, Jack E.,Dupont, William A.. "CONJUGATE ADDITION OF ORGANOLITHIUM REAGENTS TO ACRYLANILIDE ANIONS". . p. 1881 - 1882. Retrieved 2007/10/02.