Technology Process of 4-fluoro-5-isopropoxy-2-[(4-methoxybenzyl)thio]phenyl 4-fluoro-2-nitrophenyl ether
There total 5 articles about 4-fluoro-5-isopropoxy-2-[(4-methoxybenzyl)thio]phenyl 4-fluoro-2-nitrophenyl ether which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 28 percent / 3,5-dichloro-1-fluoropyridinium triflate / CH2Cl2 / 0.33 h / Heating
2: 67 percent / K2CO3 / dimethylformamide / 3.5 h / Ambient temperature
3: aq. KOH / methanol / 0.17 h / Ambient temperature
4: 1.) t-BuOK / 1.) DMF, 0 deg C, 5 min, 2.) DMF, from 0 deg C to RT
5: 1.) NaH, 2.) 18-crown-6 / 1.) diglyme, RT, 15 min, 2.) diglyme, reflux, 2 h
With
potassium hydroxide; 18-crown-6 ether; potassium tert-butylate; sodium hydride; 1-fluoro-3,5-dichloropyridinium trifluoromethanesulfonate; potassium carbonate;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570350332
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 67 percent / K2CO3 / dimethylformamide / 3.5 h / Ambient temperature
2: aq. KOH / methanol / 0.17 h / Ambient temperature
3: 1.) t-BuOK / 1.) DMF, 0 deg C, 5 min, 2.) DMF, from 0 deg C to RT
4: 1.) NaH, 2.) 18-crown-6 / 1.) diglyme, RT, 15 min, 2.) diglyme, reflux, 2 h
With
potassium hydroxide; 18-crown-6 ether; potassium tert-butylate; sodium hydride; potassium carbonate;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570350332
- Guidance literature:
-
Multi-step reaction with 3 steps
1: aq. KOH / methanol / 0.17 h / Ambient temperature
2: 1.) t-BuOK / 1.) DMF, 0 deg C, 5 min, 2.) DMF, from 0 deg C to RT
3: 1.) NaH, 2.) 18-crown-6 / 1.) diglyme, RT, 15 min, 2.) diglyme, reflux, 2 h
With
potassium hydroxide; 18-crown-6 ether; potassium tert-butylate; sodium hydride;
In
methanol;
DOI:10.1002/jhet.5570350332
