Bis-N-benzyloxycarbonyl cystine di p-nitrophenyl ester

Base Information

• Chemical Name: Bis-N-benzyloxycarbonyl cystine di p-nitrophenyl ester
• CAS No.: 13961-95-0
• Molecular Formula: C₃₄H₃₀N₄O₁₂S₂
• Molecular Weight: 750.764
• Mol file: 13961-95-0.mol

Synonyms:Bis-N-benzyloxycarbonyl cystine di p-nitrophenyl ester

Chemical Property of Bis-N-benzyloxycarbonyl cystine di p-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bis-N-benzyloxycarbonyl cystine di p-nitrophenyl ester

There total 3 articles about Bis-N-benzyloxycarbonyl cystine di p-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + N,N'-bis(benzyloxycarbonyl)-L-cystine (6968-11-2) → Bis-N-benzyloxycarbonyl cystine di p-nitrophenyl ester (13961-95-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; 1.) 4 h, 0 deg C, 2.) 48 h, room temperature;

DOI:10.1016/S0040-4020(01)88195-3

Reference yield:

L-cystine (56-89-3) → Bis-N-benzyloxycarbonyl cystine di p-nitrophenyl ester (13961-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 68.9 percent / 1 N aq. NaOH / toluene / 4 h / 0 °C

2: 62 percent / DCC / ethyl acetate / 1.) 4 h, 0 deg C, 2.) 48 h, room temperature

With sodium hydroxide; dicyclohexyl-carbodiimide; In ethyl acetate; toluene;

DOI:10.1016/S0040-4020(01)88195-3

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → Bis-N-benzyloxycarbonyl cystine di p-nitrophenyl ester (13961-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 68.9 percent / 1 N aq. NaOH / toluene / 4 h / 0 °C

2: 62 percent / DCC / ethyl acetate / 1.) 4 h, 0 deg C, 2.) 48 h, room temperature

With sodium hydroxide; dicyclohexyl-carbodiimide; In ethyl acetate; toluene;

DOI:10.1016/S0040-4020(01)88195-3

upstream raw materials:

4-nitro-phenol

N,N'-bis(benzyloxycarbonyl)-L-cystine

L-cystine

benzyl chloroformate

Downstream raw materials:

S(β-Cyanoethyl)-Z-cysteinyl histidine methyl ester

N-Z-Cysteinyl histidine methyl ester

Bis-N-benzyloxycarbonyl cystinyl di-histidine methyl ester

(Z-Cys-NH₂)2

Refernces