(3-trifluoromethyl-phenyl)-dithiocarbamic acid methyl ester

Base Information

• Chemical Name: (3-trifluoromethyl-phenyl)-dithiocarbamic acid methyl ester
• CAS No.: 69243-54-5
• Molecular Formula: C₉H₈F₃NS₂
• Molecular Weight: 251.296
• Mol file: 69243-54-5.mol

Synonyms:(3-trifluoromethyl-phenyl)-dithiocarbamic acid methyl ester

Chemical Property of (3-trifluoromethyl-phenyl)-dithiocarbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-trifluoromethyl-phenyl)-dithiocarbamic acid methyl ester

There total 2 articles about (3-trifluoromethyl-phenyl)-dithiocarbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

carbon disulfide (75-15-0,12122-00-8) + 3-trifluoromethylaniline (98-16-8) + methyl iodide (74-88-4) → (3-trifluoromethyl-phenyl)-dithiocarbamic acid methyl ester (69243-54-5)

Guidance literature:

carbon disulfide; 3-trifluoromethylaniline; With sodium hydroxide; In water; dimethyl sulfoxide; at 20 ℃; for 0.5h;

methyl iodide; In water; dimethyl sulfoxide; at 20 ℃;

Reference yield:

3-trifluoromethylaniline (98-16-8) → (3-trifluoromethyl-phenyl)-dithiocarbamic acid methyl ester (69243-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / dimethyl sulfoxide; water / 0.5 h / 20 °C

2: dimethyl sulfoxide; water

With sodium hydroxide; In water; dimethyl sulfoxide;

DOI:10.1055/s-1981-29657

Reference yield: 86.0%

(3-trifluoromethyl-phenyl)-dithiocarbamic acid methyl ester (69243-54-5) + methyl iodide (74-88-4) → (3-trifluoromethyl-phenyl)-dimethyl-dithiocarbonimidate (220464-67-5)

Guidance literature:

With sodium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

upstream raw materials:

carbon disulfide

3-trifluoromethylaniline

methyl iodide

Downstream raw materials:

2-Thioxo-3-(3-trifluoromethyl-phenyl)-2,3-dihydro-1H-quinazolin-4-one

(1H-Benzoimidazol-2-yl)-(3-trifluoromethyl-phenyl)-amine

(3-trifluoromethyl-phenyl)-dimethyl-dithiocarbonimidate

Refernces

• 1、 Garin, J.,Martinez, V.,Mayoral, J.,Melendez, E.,Merchan, F.. "A Facile Modified Preparation of Methyl N-Aryldithiocarbamates". . p. 961. Retrieved 2007/10/02.