5-Bromo-2-fluorophenol

Base Information

• Chemical Name: 5-Bromo-2-fluorophenol
• CAS No.: 112204-58-7
• Molecular Formula: C6H4BrFO
• Molecular Weight: 191
• Hs Code.: 29089990
• Mol file: 112204-58-7.mol

Synonyms:2-Fluoro-5-bromophenol;4-Bromo-1-fluoro-2-hydroxybenzene;

Chemical Property of 5-Bromo-2-fluorophenol

Chemical Property:

• Appearance/Colour: white like or light brown crystalline powder
• Vapor Pressure: 0.176mmHg at 25°C
• Melting Point: 126-131°C(lit.)
• Refractive Index: 1.57
• Boiling Point: 205.8 °C at 760 mmHg
• PKA: 7.74±0.10(Predicted)
• Flash Point: 78.2 °C
• PSA: 20.23000
• Density: 1.511 g/cm³
• LogP: 2.29380
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

5-Bromo-2-fluorophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-2-fluorophenol has been used as a reactant in the preparation of 1-aryl-1-(3-arylpropyl and -propenyl)cyclopropane derivatives as insecticides.

Technology Process of 5-Bromo-2-fluorophenol

There total 8 articles about 5-Bromo-2-fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dihydroxy-(5-bromo-2-fluorophenyl)-borane (112204-57-6) → 5-Bromo-2-fluorophenol (112204-58-7)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 20 - 40 ℃; for 14h;

Reference yield: 86.0%

4-bromo-1-fluoro-2-methoxy-benzene (103291-07-2) → 5-Bromo-2-fluorophenol (112204-58-7)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃;

Reference yield: 85.0%

1-Bromo-4-fluorobenzene (460-00-4) → 5-Bromo-2-fluorophenol (112204-58-7)

Guidance literature:

1-Bromo-4-fluorobenzene; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

With Trimethyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.5h;

upstream raw materials:

2-(5-bromo-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

dihydroxy-(5-bromo-2-fluorophenyl)-borane

1-Bromo-4-fluorobenzene

4-bromo-1-fluoro-2-methoxy-benzene

Downstream raw materials:

2-(benzyloxy)-4-bromo-1-fluorobenzene

4-bromo-2-(4,4-difluorobut-3-enyloxy)-1-fluorobenzene

5-bromo-2-fluoro-1-(isopropyloxy)benzene

4-Bromo-1-fluoro-2-propoxy-benzene

Refernces

• 1、 Lou, Shao-Jie,Chen, Qi,Wang, Yi-Feng,Xu, Dan-Qian,Du, Xiao-Hua,He, Jiang-Qi,Mao, Yang-Jie,Xu, Zhen-Yuan. "Selective C-H bond fluorination of phenols with a removable directing group: Late-stage fluorination of 2-phenoxyl nicotinate derivatives". . p. 2846 - 2849. Retrieved 2015/05/20.
• 2、 Li, Jianqing,Smith, Daniel,Qiao, Jennifer X.,Huang, Stella,Krishnananthan, Subramaniam,Wong, Henry S.,Salvati, Mark E.,Balasubramanian, Balu N.,Chen, Bang-Chi. "Preparation of monofluorophenols via the reaction of difluorobenzene derivatives with potassium trimethylsilanoate". scheme or table. p. 633 - 637. Retrieved 2009/07/01.