Piperazine-2-carboxylic acid dihydrochloride

Base Information

• Chemical Name: Piperazine-2-carboxylic acid dihydrochloride
• CAS No.: 133525-05-0
• Molecular Formula: C₅H₁₀N₂O₂*2ClH
• Molecular Weight: 203.068
• Hs Code.: 29335990
• European Community (EC) Number: 627-971-9
• DSSTox Substance ID: DTXSID00928174
• Mol file: 133525-05-0.mol

Synonyms:Piperazine-2-carboxylic acid dihydrochloride;3022-15-9;133525-05-0;2-Piperazinecarboxylic acid dihydrochloride;piperazine-2-carboxylic acid 2hcl;Piperazine-2-carboxylic acid DiHCl;MFCD00044803;2-Piperazinecarboxylic acid, dihydrochloride;piperazine-2-carboxylic acid;dihydrochloride;Piperazine-1,4-diium-2-carboxylic acid;dichloride;(+/-)-Piperazine-2-carboxylic acid dihydrochloride;MFCD01632104;MFCD03840829;(R)-piperazine-2-carboxylicaciddihydrochloride;1,2,5-Thiadiazoles;Piperazine-2-carboxylicaciddihydrochloride;Vildagliptin-boronic?acid;SCHEMBL191366;DTXSID00928174;WNSDZBQLMGKPQS-UHFFFAOYSA-N;BCP33985;AKOS005258999;AB01992;AC-1816;CS-W015473;PB21831;PB24733;SB11108;SY004767;SY004769;SY017866;TS-00347;piperazine-2-carboxylic acid dihydrochlorid;2-piperazine-carboxylic acid dihydrochloride;AM20090413;FT-0630196;FT-0643198;FT-0643291;FT-0653614;P1391;EN300-67574;(+/-)-2-piperazinecarboxylic acid dihydrochloride;Piperazine-2-carboxylic acid dihydrochloride, 98%;J-502272;W-202247;W-205424;F8889-2135;Piperazine-2-carboxylic acid--hydrogen chloride (1/2);Z1273089259;piperazine-2-carboxylic acid dihydrochloride;PIPERAZINE-2-CARBOXYLIC ACID 2HCL

Chemical Property of Piperazine-2-carboxylic acid dihydrochloride

Chemical Property:

• Appearance/Colour: white or light yellow crystalline powder
• Vapor Pressure: 0.000107mmHg at 25°C
• Melting Point: 265 °C (dec.)(lit.)
• Boiling Point: 313.6 °C at 760 mmHg
• PKA: pK1:1.5;pK2:5.41;pK3:9.53 (25°C)
• Flash Point: 143.5 °C
• PSA: 61.36000
• Density: 1.174g/cm3
• LogP: 0.89400
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 202.0275830
• Heavy Atom Count: 11
• Complexity: 116

Purity/Quality:

98% ^*data from raw suppliers

Piperazine-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNC(CN1)C(=O)O.Cl.Cl

Technology Process of Piperazine-2-carboxylic acid dihydrochloride

There total 1 articles about Piperazine-2-carboxylic acid dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl N,N'-di(trifluoroacetyl)piperazine-2-carboxylate (98236-72-7) → piperazine-2-carboxylic acid dihydrochloride (3022-15-9,126330-90-3,133525-05-0,135841-26-8)

Guidance literature:

With hydrogenchloride; for 1.5h; Heating;

DOI:10.1007/BF00515075

Reference yield: 98.76%

di-tert-butyl dicarbonate (24424-99-5) + piperazine-2-carboxylic acid dihydrochloride (3022-15-9,126330-90-3,133525-05-0,135841-26-8) → N,N'-di-tert-butyloxycarbonylpiperazine-2-carboxylic acid (181955-79-3)

Guidance literature:

di-tert-butyl dicarbonate; piperazine-2-carboxylic acid dihydrochloride; With sodium hydroxide; In 1,4-dioxane; water; at 0 - 25 ℃; for 3.5h;

With hydrogenchloride; In 1,4-dioxane; water; pH=6 - 7;

Reference yield: 96.0%

piperazine-2-carboxylic acid dihydrochloride (3022-15-9,126330-90-3,133525-05-0,135841-26-8) + benzyl chloroformate (501-53-1,94274-21-2) → N,N'-Dibenzyloxycarbonylpiperazine-2-carboxylic acid (191739-36-3)

Guidance literature:

piperazine-2-carboxylic acid dihydrochloride; benzyl chloroformate; With sodium hydroxide; In 1,4-dioxane; water; for 1.5h; pH=11;

With hydrogenchloride; In water; pH=2;

upstream raw materials:

methyl N,N'-di(trifluoroacetyl)piperazine-2-carboxylate

Downstream raw materials:

N,N'-dinitrosopiperazine-2-carboxylic acid

piperazine-1,3-dicarboxylic acid 1-tert-butyl ester

piperazine-1,3-dicarboxylic acid 1-(4-nitrobenzyl)ester

N,N'-di-tert-butyloxycarbonylpiperazine-2-carboxylic acid

Refernces