(2R,5S)-L-Menthol-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate

Base Information Edit

Chemical Name:(2R,5S)-L-Menthol-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate
CAS No.:147027-10-9
Molecular Formula:C18H27N3O4S
Molecular Weight:381.496
Hs Code.:
European Community (EC) Number:425-250-1
Mol file:147027-10-9.mol

Synonyms:SCHEMBL12964489;147027-10-9;(2R,5S)-L-Menthol-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate

Suppliers and Price of (2R,5S)-L-Menthol-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2R,5S)-L-Menthol-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate
5g
$ 425.00

Medical Isotopes, Inc.
(2R,5S)-L-Menthyl-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate
50 mg
$ 1880.00

Matrix Scientific
(2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate 95+%
5g
$ 325.00

Matrix Scientific
(2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate 95+%
250mg
$ 152.00

Matrix Scientific
(2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate 95+%
1g
$ 98.00

Crysdot
(2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate 95+%
5g
$ 475.00

Chemenu
(2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate 95%
5g
$ 445.00

American Custom Chemicals Corporation
(2R,5S)-L-MENTHYL-5-(4-AMINO-2-OXO-1(2H)-PYRIMIDINYL)-1,3-OXATHIOLANE-2-CARBOXYLATE 95.00%
100MG
$ 1612.96

American Custom Chemicals Corporation
(2R,5S)-L-MENTHYL-5-(4-AMINO-2-OXO-1(2H)-PYRIMIDINYL)-1,3-OXATHIOLANE-2-CARBOXYLATE 95.00%
10MG
$ 679.14

Total 104 raw suppliers

Chemical Property of (2R,5S)-L-Menthol-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate Edit

Chemical Property:

Appearance/Colour:tan solid
Vapor Pressure:0mmHg at 25°C
Melting Point:203-210°C
Refractive Index:1.655
Boiling Point:524.954 °C at 760 mmHg
PKA:4.18±0.10(Predicted)
Flash Point:271.283 °C
PSA：121.74000
Density:1.421 g/cm³
LogP:2.99880
Storage Temp.:-20°C Freezer
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:381.17222752
Heavy Atom Count:26
Complexity:622

Purity/Quality:

99.9% ^*data from raw suppliers

(2R,5S)-L-Menthol-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CCC(C(C1)OC(=O)C2OC(CS2)N3C=CC(=NC3=O)N)C(C)C
Isomeric SMILES:C[C@@H]1CC[C@H]([C@@H](C1)OC(=O)C2O[C@@H](CS2)N3C=CC(=NC3=O)N)C(C)C
Uses Lamivudine intermediate. A Lamivudine (L172500) intermediate.

Technology Process of (2R,5S)-L-Menthol-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate

There total 34 articles about (2R,5S)-L-Menthol-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18037-10-0
2,4-O,N-bis(trimethylsilyl)cytosine

: 147027-09-6,147126-67-8
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-(methylcarbonyloxy)-1,3-oxathiolane-2-carboxylate

: 147027-10-9,147126-73-6,147126-74-7,147126-80-5
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathiolane-2-carboxylate

Guidance literature:: With pyridinium triflate; In acetonitrile; at 80 ℃; for 0.14h; under 517.162 Torr; Flow reactor;
DOI:10.1039/c7ob00480j

Reference yield: 90.0%

: 71-30-7
Cytosine

: 288325-76-8
5S-chloro-[1,3]oxathiolane-2R-carboxilic acid 2-(1'R,2'S,5'R)-isopropyl-5-methyl-cyclohexyl ester

: 147027-10-9,147126-73-6,147126-74-7,147126-80-5
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathiolane-2-carboxylate

Guidance literature:: With methanesulfonic acid; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; toluene; at 25 - 60 ℃; for 4h; Reflux;

Reference yield: 80.0%

: 71-30-7
Cytosine

: 147027-09-6,147126-67-8
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-(methylcarbonyloxy)-1,3-oxathiolane-2-carboxylate

: 147027-10-9,147126-73-6,147126-74-7,147126-80-5
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathiolane-2-carboxylate

Guidance literature:: Cytosine; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; at 25 - 55 ℃; Inert atmosphere;

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-(methylcarbonyloxy)-1,3-oxathiolane-2-carboxylate; With zirconium(IV) chloride; In dichloromethane; at 25 - 30 ℃; for 6h; Reagent/catalyst; Solvent; Concentration; Time; Inert atmosphere;