2-(4-chlorophenyl)-2-methylpropanoyl Chloride

Base Information

• Chemical Name: 2-(4-chlorophenyl)-2-methylpropanoyl Chloride
• CAS No.: 40919-11-7
• Molecular Formula: C₁₀H₁₀Cl₂O
• Molecular Weight: 217.095
• Mol file: 40919-11-7.mol

Synonyms:2-(4-chlorophenyl)-2-methylpropanoyl Chloride

Chemical Property of 2-(4-chlorophenyl)-2-methylpropanoyl Chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chlorophenyl)-2-methylpropanoyl Chloride

There total 3 articles about 2-(4-chlorophenyl)-2-methylpropanoyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(4-chlorophenyl)-2-methylpropanoic acid (6258-30-6) → 2-(4-chlorophenyl)-2-methylpropanoyl Chloride (40919-11-7)

Guidance literature:

With thionyl chloride; In toluene; at 80 ℃; for 2h;

DOI:10.1016/j.bmcl.2007.04.105

Reference yield:

methyl phosphite (96-36-6,868-85-9) + N-butylamine (109-73-9,85404-21-3) + dimethyl p-chlorophenylisobutyrylphosphonate (81928-56-5) → 2-(4-chlorophenyl)-2-methylpropanoyl Chloride (40919-11-7)

Guidance literature:

Reference yield:

2-(4-chlorophenyl)-2-methylpropanenitrile (30568-32-2) → 2-(4-chlorophenyl)-2-methylpropanoyl Chloride (40919-11-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / water; ethylene glycol / 48 h / 100 °C

2: oxalyl dichloride

With oxalyl dichloride; potassium hydroxide; In water; ethylene glycol;

DOI:10.1021/acs.joc.5b00505

upstream raw materials:

2-(4-chlorophenyl)-2-methylpropanoic acid

methyl phosphite

N-butylamine

dimethyl p-chlorophenylisobutyrylphosphonate

Downstream raw materials:

C₁₃H₁₅ClN₂O

2-{4-[2-(2-(4-Chlorophenyl)-2-methylpropionylamino)ethyl]-phenoxy}-2-methylpropionic acid

Refernces

• 1、 -. "COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT AND PDFGR". Paragraph 0140 -0142. . Retrieved 2017/02/24.
• 2、 Xu, Fan,Qian, Xiang-Yang,Li, Yan-Jie,Xu, Hai-Chao. "Synthesis of 4H-1,3-Benzoxazines via Metal- and Oxidizing Reagent-Free Aromatic C-H Oxygenation". supporting information. p. 6332 - 6335. Retrieved 2017/12/08.