Meridia

Base Information

• Chemical Name: Meridia
• CAS No.: 125494-59-9
• Molecular Formula: C17H29Cl2NO
• Molecular Weight: 334.33
• Hs Code.: 2921519090
• European Community (EC) Number: 603-075-3
• UNII: OGM0YHD1WF
• DSSTox Substance ID: DTXSID00925148
• Wikidata: Q27285644
• NCI Thesaurus Code: C47718
• ChEMBL ID: CHEMBL3989830
• Mol file: 125494-59-9.mol

Synonyms:(R)-DDMS;BTS 54 524;BTS 54524;BTS-54524;di-desmethylsibutramine;didesmethylsibutramine;Meridia;mono-desmethylsibutramine;N-1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutyl-N,N-dimethylamine HCl;Reductil;sibutramine;sibutramine hydrochloride

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Meridia

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 7.45E-05mmHg at 25°C
• Melting Point: 193-195.5 °C
• Boiling Point: 342.6 °C at 760 mmHg
• Flash Point: 161 °C
• PSA: 12.47000
• Density: 1.026 g/cm3
• LogP: 5.47570
• Storage Temp.: Room temp
• Solubility.: DMSO: >30mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 333.1626199
• Heavy Atom Count: 21
• Complexity: 275

Purity/Quality:

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T,F
• Statements: 36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 22-24/25-36-26-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)N(C)C.O.Cl
• Recent ClinicalTrials: A Comparative Study of KES524 in Patients With Obesity Disease
• Recent EU Clinical Trials: TRATAMIENTO MULTIDISCIPLINARIO DE LA OBESIDAD MóRBIDA: MEDICAMENTOS, TERAPIA DE COMPORTAMIENTO, APOYO NUTRICIONAL Y ACTIVIDAD FíSICA. ESTDIO TRAMOMTANA
• Description: Sibutramine was introduced as Meridia in the US for the control of obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by creating a satieted feeling and increases energy expenditure by enhancing thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of Sibutramine once-daily, meaningful weight loss was sustained for 12 months ; an additional study demonstrated a lack of abuse potential. An appreciable part of Sibutramine's effect would also be due to its 2N-mono and didesmethylmetabolites, which are very potent monoamine reuptake inhibitors themselves.
• Uses: A serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure antiobesity agent;neurotransmitter reuptake inhibitor antihyperlipidemic