Cyclobutylmethanamine

Base Information

• Chemical Name: Cyclobutylmethanamine
• CAS No.: 4415-83-2
• Molecular Formula: C5H11N
• Molecular Weight: 85.149
• Hs Code.: 2921300090
• European Community (EC) Number: 695-238-0
• DSSTox Substance ID: DTXSID40328376
• Nikkaji Number: J80.829F
• Wikidata: Q72459422
• Mol file: 4415-83-2.mol

Synonyms:cyclobutylmethanamine;4415-83-2;Cyclobutanemethanamine;CYCLOBUTYLMETHYLAMINE;1-Cyclobutylmethylamine;1-cyclobutylmethanamine;cyclobutanemethylamine;cyclobutylmethyl amine;(Aminomethyl)cyclobutane;C-Cyclobutyl-methylamine;cyclobutylmethylamine, AldrichCPR;cyclobutylmethanamine,hydrochloride;DTXSID40328376;MFCD06212616;AKOS000164040;CS-W022619;SB10275;AS-57661;A7029;AM20070613;FT-0650014;EN300-40412;A826503;J-520140

Chemical Property of Cyclobutylmethanamine

Chemical Property:

• Vapor Pressure: 55.9mmHg at 25°C
• Refractive Index: 1.469
• Boiling Point: 90.6 °C at 760 mmHg
• PKA: 10.50±0.29(Predicted)
• Flash Point: 2.1 °C
• PSA: 26.02000
• Density: 0.889 g/cm³
• LogP: 1.44550
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 85.089149355
• Heavy Atom Count: 6
• Complexity: 39.2

Purity/Quality:

99% ^*data from raw suppliers

Cyclobutylmethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(C1)CN

Technology Process of Cyclobutylmethanamine

There total 4 articles about Cyclobutylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclobutanecarbonitrile (4426-11-3) → cyclobutylmethylamine (4415-83-2)

Guidance literature:

With hydrogenchloride; palladium on activated charcoal; Hydrogenation;

DOI:10.1021/ja01187a063

Reference yield:

2-aza-bicyclo[2.2.0]hex-5-ene (59501-58-5) → cyclobutylmethylamine (4415-83-2)

Guidance literature:

(reduction);

DOI:10.1021/ja00710a088

Reference yield:

cyclobutyl amide (1503-98-6) → cyclobutylmethylamine (4415-83-2)

Guidance literature:

Multi-step reaction with 2 steps

1: P₂O₅ / durch Destillation

2: sodium; alcohol

With ethanol; sodium; phosphorus pentoxide;

upstream raw materials:

cyclobutanecarbonitrile

2-aza-bicyclo[2.2.0]hex-5-ene

cyclobutyl amide

Downstream raw materials:

N-(cyclobutylmethyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine

N-{4-[(cyclobutylmethyl)amino]-3-nitrophenyl}-N-methylacetamide

4-((cyclobutylmethylamino)methyl)-N-((1R,3S)-3-hydroxycyclohexyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide

Refernces

• 1、 -. "RENIN INHIBITORS". Page/Page column 47. . Retrieved 2008/06/13.