phosphonate de diisopropyle

Base Information

• Chemical Name: phosphonate de diisopropyle
• CAS No.: 124050-46-0
• Molecular Formula: C₁₄H₂₀FO₄P
• Molecular Weight: 302.283
• Mol file: 124050-46-0.mol

Synonyms:phosphonate de diisopropyle

Chemical Property of phosphonate de diisopropyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phosphonate de diisopropyle

There total 3 articles about phosphonate de diisopropyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(Chlorocarbonyl-fluoro-methyl)-phosphonic acid diisopropyl ester (97480-48-3) + phenyllithium (591-51-5) → phosphonate de diisopropyle (124050-46-0)

Guidance literature:

With copper(I) bromide; In tetrahydrofuran; diethyl ether; 1.) from -78 deg C to -45 deg C; 2.) -45 deg C, 2.5 h;

Reference yield: 72.0%

(Chlorocarbonyl-fluoro-methyl)-phosphonic acid diisopropyl ester (97480-48-3) → phosphonate de diisopropyle (124050-46-0)

Guidance literature:

at -78 - -45 ℃; for 3h;

DOI:10.1016/0040-4039(88)85251-1

Reference yield:

(Diisopropoxy-phosphoryl)-fluoro-acetic acid (97480-36-9) → phosphonate de diisopropyle (124050-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂

2: 72 percent / 3 h / -78 - -45 °C

With thionyl chloride; In dichloromethane;

DOI:10.1016/0040-4039(88)85251-1

upstream raw materials:

(Chlorocarbonyl-fluoro-methyl)-phosphonic acid diisopropyl ester

phenyllithium

(Diisopropoxy-phosphoryl)-fluoro-acetic acid

Downstream raw materials:

(E)-2-fluoro-1,3-diphenylprop-2-en-1-one

(Z)-1,3-diphenyl-2-fluoro-2-propen-1-one

Refernces

• 1、 Coutrot, Ph.,Grison, C.. "SYNTHESE GENERALE DE β-CETOPHOSPHONATES α-FLUORES PRECURSEURS D'ENONES α-FLUOREES, APPLICATION EN SERIE PYRETHRENIQUE.". . p. 2655 - 2658. Retrieved 2007/10/02.