Propanamide, 2-hydroxy-2-methyl-

Base Information

• Chemical Name: Propanamide, 2-hydroxy-2-methyl-
• CAS No.: 13027-88-8
• Molecular Formula: C4H9NO2
• Molecular Weight: 103.121
• Hs Code.: 2924199090
• European Community (EC) Number: 235-890-1
• DSSTox Substance ID: DTXSID8065327
• Nikkaji Number: J243.107F
• Wikidata: Q72491451
• Mol file: 13027-88-8.mol

Synonyms:13027-88-8;2-hydroxy-2-methylpropanamide;2-Hydroxyisobutyramide;2-Methyl-2-hydroxypropionamide;Propanamide, 2-hydroxy-2-methyl-;2-Hydroxy-2-methylpropionamide;alpha-hydroxyisobutyramide;EINECS 235-890-1;MFCD08063365;hydroxyisobutyramide;alpha-hydroxy-isobutyramide;SCHEMBL322454;2-HYDROXY ISOBUTYRAMIDE;2-Hydroxy-2-methylpropaneamide;2-hydroxy-2-methyl-propionamide;DTXSID8065327;2-Hydroxy isobutyric acid, amide;alpha-hydroxyisobutyric acid amide;AC8009;AKOS011506931;GS-3184;SY035592;CS-0154975;FT-0636776;H1181;EN300-317038;A806051;J-005779

Chemical Property of Propanamide, 2-hydroxy-2-methyl-

Chemical Property:

• Vapor Pressure: 0.00201mmHg at 25°C
• Melting Point: 93 °C
• Refractive Index: 1.464
• Boiling Point: 258.5 °C at 760 mmHg
• Flash Point: 110.2 °C
• PSA: 63.32000
• Density: 1.109 g/cm³
• LogP: -0.05710
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 103.063328530
• Heavy Atom Count: 7
• Complexity: 87.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C(=O)N)O

Technology Process of Propanamide, 2-hydroxy-2-methyl-

There total 21 articles about Propanamide, 2-hydroxy-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

manganese(II) sulfate + 2-hydroxy-2-methylpropanenitrile (75-86-5) → 2-hydroxyisobutyramide (13027-88-8)

Guidance literature:

With potassium permanganate; manganese dioxide; sulfuric acid; In water; acetone;

Reference yield: 96.0%

2-hydroxy-2-methylpropanenitrile (75-86-5) → 2-hydroxyisobutyramide (13027-88-8)

Guidance literature:

With water; acetone; manganese(IV) oxide; at 45 ℃; for 7h; Product distribution; without acetone; different times and initial concentrations; other temperature;

Reference yield: 86.8%

2-hydroxy-2-methylpropanenitrile (75-86-5) → hydrogen cyanide (74-90-8) + 2-hydroxyisobutyramide (13027-88-8) + acetone (67-64-1)

Guidance literature:

With water; manganese(IV) oxide; In 1,4-dioxane; at 60 ℃; for 1h; Product distribution; Kinetics; other time, temperature; without catal.; in presence of acetone; energy of activation;;

upstream raw materials:

tetrachloromethane

α-(α-hydroxy-isobutyryloxy)-isobutyric acid amide

2-hydroxy-2-methylpropanenitrile

hydrogen cyanide

Downstream raw materials:

2,2,5,5-tetramethyl-oxazolidin-4-one

methyl 2-hydroxy-2-methylpropionate

α-methoxyisobutyramide

3,3,6,6-Tetramethyl-1,4-dioxane-2,5-dione

Refernces

• 1、 Knapp, Spring Melody M.,Sherbow, Tobias J.,Juliette, J. Jerrick,Tyler, David R.. "Cyanohydrin hydration with [Ru(η6-p-cymene)Cl 2PR3] complexes". . p. 2941 - 2944. Retrieved 2012.
• 2、 -. "Catalyst, preparation method thereof and preparation method of amide compound". Paragraph 0142-0146; 0147. . Retrieved 2020/01/12.
• 3、 Xing, Xiangyou,Xu, Chen,Chen, Bo,Li, Chengcheng,Virgil, Scott C.,Grubbs, Robert H.. "Highly Active Platinum Catalysts for Nitrile and Cyanohydrin Hydration: Catalyst Design and Ligand Screening via High-Throughput Techniques". supporting information. p. 17782 - 17789. Retrieved 2019/01/04.