Technology Process of 5-methyl-2-[2-(5-methylpyridin-2-yl)-6-vinylphenyl]pyridine
There total 5 articles about 5-methyl-2-[2-(5-methylpyridin-2-yl)-6-vinylphenyl]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(but-3-en-1-ynyl)-5-methylpyridine;
With
cobalt[1,3-bis(diphenylphosphino)propane] dibromide; zinc(II) iodide; zinc;
In
dimethyl sulfoxide;
at 20 ℃;
With
ethylenediaminetetraacetic acid;
In
dimethyl sulfoxide;
pH=10;
regioselective reaction;
DOI:10.1055/s-0033-1338384
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper(l) iodide; diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 48 h / 20 °C
2.1: cobalt[1,3-bis(diphenylphosphino)propane] dibromide; zinc; zinc(II) iodide / dimethyl sulfoxide / 20 °C
2.2: 3407 / pH 10
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; cobalt[1,3-bis(diphenylphosphino)propane] dibromide; diisopropylamine; triphenylphosphine; zinc(II) iodide; zinc;
In
tetrahydrofuran; dimethyl sulfoxide;
1.1: |Sonogashira Cross-Coupling;
DOI:10.1055/s-0033-1338384
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(l) iodide; diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / toluene / 48 h / 20 °C
2.1: potassium carbonate / toluene; methanol / 20 °C
3.1: copper(l) iodide; diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 48 h / 20 °C
4.1: cobalt[1,3-bis(diphenylphosphino)propane] dibromide; zinc; zinc(II) iodide / dimethyl sulfoxide / 20 °C
4.2: 3407 / pH 10
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; cobalt[1,3-bis(diphenylphosphino)propane] dibromide; potassium carbonate; diisopropylamine; triphenylphosphine; zinc(II) iodide; zinc;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; toluene;
1.1: |Sonogashira Cross-Coupling / 3.1: |Sonogashira Cross-Coupling;
DOI:10.1055/s-0033-1338384