N-Methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde

Base Information

• Chemical Name: N-Methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde
• CAS No.: 1201-91-8
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Hs Code.: 2922509090
• European Community (EC) Number: 628-543-4
• DSSTox Substance ID: DTXSID20394271
• Nikkaji Number: J60.283C
• Wikidata: Q72491309
• Mol file: 1201-91-8.mol

Synonyms:1201-91-8;N-Methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde;4-((2-Hydroxyethyl)(methyl)amino)benzaldehyde;4-[2-hydroxyethyl(methyl)amino]benzaldehyde;4-(n-Methyl-n-hydroxyethyl)amino benzaldehyde;4-[(2-hydroxyethyl)(methyl)amino]benzaldehyde;Benzaldehyde, 4-[(2-hydroxyethyl)methylamino]-;SCHEMBL62025;DTXSID20394271;JOCUIVLSLBBESN-UHFFFAOYSA-N;AC-609;MFCD00963547;AKOS000120859;BP-13057;4-((2-Hydroxyethyl)methylamino)benzaldehyde;CS-0134780;FT-0633475;4-[Methyl-(2-hydroxyethyl)amino]benzaldehyde;EN300-20869;4-[N-2-hydroxyethyl-N-methylamino]benzaldehyde;D94465;p-[(N-Methyl-N-Hydroxyethyl)Amino]Benzaldehyde;1T-0016;4-[N-(2-Hydroxyethyl)-N-methylamino]benzaldehyde;A804460;AN-584/43522514;4-[N-(2-hydroxyethyl)-N-methylamino] benzaldehyde;J-004275;N-Methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde, 96%;Z104484150

Chemical Property of N-Methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde

Chemical Property:

• Appearance/Colour: Light yellow powder
• Vapor Pressure: 1.27E-05mmHg at 25°C
• Melting Point: 66-70 °C(lit.)
• Refractive Index: 1.615
• Boiling Point: 354.037 °C at 760 mmHg
• PKA: 14.58±0.10(Predicted)
• Flash Point: 167.916 °C
• PSA: 40.54000
• Density: 1.171 g/cm³
• LogP: 0.92760
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 153

Purity/Quality:

99% ^*data from raw suppliers

4-[(2-Hydroxyethyl)methylamino]benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CCO)C1=CC=C(C=C1)C=O
• Uses: 4-[(2-hydroxyethyl)methylamino]-Benzaldehyde is used in the synthesis crosslinkable tricyanopyrroline polymeric electro-optic materials. 4-[(2-hydroxyethyl)methylamino]-Benzaldehyde is also used in th e chemical process when synthesizing polymethacrylates. N-Methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde may be used to synthesize:2,5-bis[4-(methylaminoethanol)benzylidene]cyclopentanone4′-[(2-tosyloxyethyl)(methyl)amino]-4-phenyl-3-buten-2-malonitrile, a tosylate precursormethanesulfonic acid 2-[(4-formyl-phenyl)-methyl-amino]-ethyl ester

Technology Process of N-Methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde

There total 11 articles about N-Methyl-N-(2-hydroxyethyl)-4-aminobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-((4-(hydroxymethyl)phenyl)(methyl)amino)ethanol → 4-(N-methyl-N-hydroxyethylamino)benzaldehyde (1201-91-8)

Guidance literature:

With iron(III) chloride hexahydrate; C₁₇H₂₆N₃⁽¹⁺⁾*Br^(1-); dihydrogen peroxide; In water; at 20 ℃; for 3h; chemoselective reaction;

DOI:10.1039/c6nj03793c

Reference yield: 79.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 4-fluorobenzaldehyde (459-57-4) → 4-(N-methyl-N-hydroxyethylamino)benzaldehyde (1201-91-8)

Guidance literature:

(2-hydroxyethyl)(methyl)amine; With Aliquat 336; potassium carbonate; In dimethyl sulfoxide; at 95 ℃; for 0.166667h;

4-fluorobenzaldehyde; In dimethyl sulfoxide; at 95 ℃; for 72h; pH=2;

Reference yield: 60.0%

N-(2-hydroxyethyl)-N-methylaminobenzene (93-90-3) → 4-(N-methyl-N-hydroxyethylamino)benzaldehyde (1201-91-8)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; at 5 ℃; for 0.5h;

N-(2-hydroxyethyl)-N-methylaminobenzene; at 20 ℃; for 3h;

upstream raw materials:

N-(2-chloroethyl)-N-methyl-4-aminobenzaldehyde

2-(methyl(phenyl)amino)ethyl acetate

N,N-dimethyl-formamide

formaldehyd

Downstream raw materials:

N-(2-hydroxyethyl)-N-methyl-4-(1-hydroxy-2-phenylethyl)aniline

4-(N-2-acryloyloxyethyl-N-methylamino)benzaldehyde

2-[N-methyl-N-(2-hydroxyethyl)-4-aminophenyl]benzothiazole

(E)-2-(2-(4-((2-hydroxyethyl)(methyl)amino)styryl)-6-methyl-4H-pyran-4-ylidene)malononitrile

Refernces

• 1、 Lupo, Donald,Ringsdorf, Helmut,Schuster, Andreas,Seitz, Markus. "Amphiphilic nonlinear optical bis-chromophores and their mixtures with amphotropic copolymers: Preparation of monolayers and Langmuir - Blodgett multilayers". . p. 10498 - 10506. Retrieved 1994.
• 2、 -. "Mitochondria two-photon fluorescence viscosity probe and preparation method thereof". Paragraph 0048-0049. . Retrieved 2017/08/28.