Technology Process of 6-cyano-5-[4-(2-hydroxyethoxy)phenyl]-1H-indole-3-carboxylic acid
There total 5 articles about 6-cyano-5-[4-(2-hydroxyethoxy)phenyl]-1H-indole-3-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene;
In
tetrahydrofuran; water; tert-butyl alcohol;
at 20 ℃;
for 15.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: manganese(IV) oxide / chloroform / 2 h / 60 °C
2.1: trichlorophosphate / 0.17 h / 20 °C / Inert atmosphere
2.2: 0.5 h / 20 - 80 °C / Inert atmosphere
2.3: 20 - 85 °C / Inert atmosphere
3.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3.5 h / 110 °C / Inert atmosphere
4.1: potassium carbonate / water; ethanol; toluene / 2 h / 90 °C / Microwave irradiation; Inert atmosphere
5.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate monohydrate / water; tert-butyl alcohol; tetrahydrofuran / 15.5 h / 20 °C
With
manganese(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; potassium acetate; potassium carbonate; trichlorophosphate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; water; toluene; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trichlorophosphate / 0.17 h / 20 °C / Inert atmosphere
1.2: 0.5 h / 20 - 80 °C / Inert atmosphere
1.3: 20 - 85 °C / Inert atmosphere
2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3.5 h / 110 °C / Inert atmosphere
3.1: potassium carbonate / water; ethanol; toluene / 2 h / 90 °C / Microwave irradiation; Inert atmosphere
4.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate monohydrate / water; tert-butyl alcohol; tetrahydrofuran / 15.5 h / 20 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; potassium acetate; potassium carbonate; trichlorophosphate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene; tert-butyl alcohol;