Citric Acid Monohydrate

Base Information

• Chemical Name: Citric Acid Monohydrate
• CAS No.: 5949-29-1
• Molecular Formula: C6H10O8
• Molecular Weight: 210.141
• Hs Code.: 2918.14 Oral rat LD50: 3000 mg/kg
• European Community (EC) Number: 611-842-9,691-328-9
• ICSC Number: 0704
• UNII: 2968PHW8QP
• DSSTox Substance ID: DTXSID7074668
• Wikidata: Q27114303
• NCI Thesaurus Code: C47452
• RXCUI: 221079
• Metabolomics Workbench ID: 67680
• ChEMBL ID: CHEMBL2107737
• Mol file: 5949-29-1.mol

Synonyms:Anhydrous Citric Acid;Citrate;Citric Acid;Citric Acid Monohydrate;Citric Acid, Anhydrous;Uralyt U

Chemical Property of Citric Acid Monohydrate

Chemical Property:

• Appearance/Colour: white crystals or powder
• Vapor Pressure: 184 mm Hg ( 20 °C)
• Melting Point: -94 °C(lit.)
• Refractive Index: n20/D 1.359(lit.)
• Boiling Point: 309.6 °C at 760 mmHg
• PKA: 3.138, 4.76, 6.401
• Flash Point: 155.2 °C
• PSA: 141.36000
• Density: 0.791 g/mL at 25 °C(lit.)
• LogP: -1.31280
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• Solubility.: H2O: soluble54% (w/w) at 10°C (Citric acid in water)
• Water Solubility.: 1630 g/L (20 ºC)
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 210.03756727
• Heavy Atom Count: 14
• Complexity: 227

Purity/Quality:

99% HPLC ^*data from raw suppliers

Citric Acid, Monohydrate, ACS ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F, Xi
• Hazard Codes: F,Xi
• Statements: 11-36-66-67-41-36/37/38-37/38
• Safety Statements: 9-16-26-37/39-36/37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Organic Acids
• Canonical SMILES: C(C(=O)O)C(CC(=O)O)(C(=O)O)O.O
• Recent EU Clinical Trials: Efficacy of infusions of mesenchymal stem cells from Wharton jelly in the moderate to severe SARS-Cov-2 related acute respiratory distress syndrome (COVID-19):
• Inhalation Risk: No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.
• Effects of Short Term Exposure: The aerosol is irritating to the eyes, skin and respiratory tract.
• Production and Forms: Common Form: Citric acid monohydrate is the usual form sold commercially, produced via crystallization from cold, saturated solutions through slow evaporation.; Anhydrous Form: Citric acid anhydrous is produced from hot, saturated solutions of citric acid.
• Source and History: Natural Source: Citric acid is a weak tricarboxylic acid found in citrus fruits like lemons, historically the main source until 1919.; Industrial Production: Production scaled up with the use of the fungus Aspergillus niger for citric acid production.
• Deliquescence and Stability: Deliquescence: Citric acid monohydrate is more resistant to humidity compared to anhydrous citric acid, deliquescing at a higher relative humidity (RH).; Stability: Thermal-gravimetric analysis (TGA) shows the stability of citric acid monohydrate up to about 600 degrees after significant weight loss due to decomposition.
• Properties and Uses: Photoreduction: Water-soluble citric acid monohydrate (CAM) displays efficient photoreduction activity for Cr(VI), attributed to synergism of components like H+, C5H7O5COO鈭?, and light (hv).; Plasticizing Effects: Demonstrated plasticizing effects on acrylic polymers.; Extraction Medium: Used as a medium in extracting pectin, demonstrating potential as a sustainable and less toxic alternative solvent compared to mineral acids.

Technology Process of Citric Acid Monohydrate

There total 2 articles about Citric Acid Monohydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium chlorite (7758-19-2) → citric acid monohydrate (5949-29-1)

Guidance literature:

With sodium hydroxide;

Reference yield:

→ citric acid monohydrate (5949-29-1)

Guidance literature:

Reference yield: 98.8%

2-(4-(3-(5-ethyl-4-oxo-7-propyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)-4-propoxyphenylsulfonyl)piperazin-1-yl)ethyl 6-(nitrooxy)hexanoate + citric acid monohydrate (5949-29-1) → 2-(4-(3-(5-ethyl-4-oxo-7-propyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)-4-propoxyphenylsulfonyl)piperazin-1-yl)ethyl 6-(nitrooxy)hexanoate citrate

Guidance literature:

In methanol; at 20 ℃; for 0.166667h;

upstream raw materials:

sodium chlorite

Downstream raw materials:

6-methoxyquinoline-4-carbaldehyde

5-vinyl-1-aza-bicyclo[2.2.2]octane-2-carboxylic acid

2-Dimethoxymethyl-5-vinyl-1-aza-bicyclo[2.2.2]octane

7'-(1,3-dimethoxycarbonyl-2-hydroxyprop-2-yl)-deoxyquinine

Refernces

• 1、 -. "Enzyme-treated hesperidin, process for producing the same and method of using enzyme-treated hesperidin". . . Retrieved 2008/06/13.
• 2、 -. "Citric acid extraction". . . Retrieved 2008/06/13.