2-Fluoro-3-nitrobenzyl broMide

Base Information

• Chemical Name: 2-Fluoro-3-nitrobenzyl broMide
• CAS No.: 946125-65-1
• Molecular Formula: C₇H₅BrFNO₂
• Molecular Weight: 234.025
• Hs Code.: 2904990090
• Mol file: 946125-65-1.mol

Synonyms:1-(bromomethyl)-2-fluoro-3- nitrobenzene

Chemical Property of 2-Fluoro-3-nitrobenzyl broMide

Chemical Property:

• Boiling Point: 311.7±27.0 °C(Predicted)
• Density: 1.733±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-Fluoro-3-nitrobenzyl bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-3-nitrobenzyl broMide

There total 7 articles about 2-Fluoro-3-nitrobenzyl broMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-fluoro-3-nitrotoluene (437-86-5) → 1-(bromomethyl)-2-fluoro-3- nitrobenzene (946125-65-1)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 24h; Reflux;

Reference yield: 73.0%

→ 1-(bromomethyl)-2-fluoro-3- nitrobenzene (946125-65-1)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 12h;

Reference yield: 70.0%

(2-fluoro-3-nitrophenyl)methanol (946126-95-0) → 1-(bromomethyl)-2-fluoro-3- nitrobenzene (946125-65-1)

Guidance literature:

With phosphorus tribromide; In diethyl ether; at 0 ℃; for 0.5h; Product distribution / selectivity;

upstream raw materials:

2-fluoro-3-nitrotoluene

(2-fluoro-3-nitrophenyl)methanol

2-chloro-3-nitrotoluene

2-chloro-3-nitrobenzoic acid methyl ester

Downstream raw materials:

2-(2-fluoro-3-nitrobenzyl)-3-oxo-butyric acid ethyl ester

2-(2-(2-fluoro-3-nitrobenzyl)-3-methylbenzo[b]thiophen-6-yloxy)pyrimidine

3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran

2-oxo-2H-3-(2-fluoro-3-aminobenzyl)-4-methyl-7-hydroxy-1-benzopyran

Refernces

• 1、 Liang, Lei,Niu, Yan,Peng, Yihong,Wang, Chao,Wang, Han,Xi, Dandan,Xu, Fengrong,Xu, Ping. "Hybrids of MEK inhibitor and NO donor as multitarget antitumor drugs". . . Retrieved 2020/04/17.
• 2、 Caille, Seb,Allgeier, Alan M.,Bernard, Charles,Correll, Tiffany L.,Cosbie, Andrew,Crockett, Richard D.,Cui, Sheng,Faul, Margaret M.,Hansen, Karl B.,Huggins, Seth,Langille, Neil,Mennen, Steven M.,Morgan, Bradley P.,Morrison, Henry,Muci, Alexander,Nagapudi, Karthik,Quasdorf, Kyle,Ranganathan, Krishnakumar,Roosen, Philipp,Shi, Xianqing,Thiel, Oliver R.,Wang, Fang,Tvetan, Justin T.,Woo, Jacqueline C. S.,Wu, Steven,Walker, Shawn D.. "Development of a Factory Process for Omecamtiv Mecarbil, a Novel Cardiac Myosin Activator". . p. 1558 - 1567. Retrieved 2019/09/04.