Technology Process of benzyl {2-[4-(3-chloropropoxy)phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazol-5-yl}carbamate
There total 12 articles about benzyl {2-[4-(3-chloropropoxy)phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazol-5-yl}carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-[4-(3-chloropropoxy)phenyl]-5,6-dihydro-4H-cyclopenta[1,3]thiazole-5-carboxylic acid;
With
diphenyl phosphoryl azide; triethylamine;
In
toluene;
at 40 ℃;
benzyl alcohol;
In
toluene;
at 90 ℃;
for 24h;
- Guidance literature:
-
2-[4-(3-chloropropoxy)phenyl]-5,6-dihydro-4H-cyclopenta[1,3]thiazole-5-carboxylic acid;
With
diphenyl phosphoryl azide; triethylamine;
In
toluene;
at 20 ℃;
for 12h;
benzyl alcohol;
In
toluene;
for 24h;
Reflux;
DOI:10.1002/cmdc.201100248
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide; water; calcium carbonate / acetonitrile / 4 h / 20 °C
2.1: Dess-Martin periodane / dichloromethane / 48 h / 20 °C
3.1: ethanol / 12 h / Reflux
4.1: water; lithium hydroxide / tetrahydrofuran / 12 h / 20 °C
5.1: diphenyl phosphoryl azide; triethylamine / toluene / 12 h / 20 °C
5.2: 24 h / Reflux
With
N-Bromosuccinimide; diphenyl phosphoryl azide; water; Dess-Martin periodane; triethylamine; calcium carbonate; lithium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; toluene; acetonitrile;
3.1: Hantzsch condensation / 5.2: Curtius rearrangement;
DOI:10.1002/cmdc.201100248