Technology Process of 2-Propenoic acid, 3-[4-(bromomethyl)phenyl]-, methyl ester
There total 3 articles about 2-Propenoic acid, 3-[4-(bromomethyl)phenyl]-, methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 3-(4-methylphenyl)acrylate;
In
1,2-dichloro-ethane;
at 120 ℃;
for 1.5h;
under 3800.26 Torr;
Inert atmosphere;
With
tetrabutylammomium bromide; acetic acid;
In
1,2-dichloro-ethane;
at 150 ℃;
for 7h;
under 6080.41 Torr;
Reagent/catalyst;
Solvent;
Temperature;
Pressure;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: piperidine / N,N-dimethyl-formamide / 4 h / Reflux
2.1: thionyl chloride / 1 h / 0 °C
2.2: 4 h / 65 °C
3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 20 °C
With
piperidine; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile);
In
tetrachloromethane; N,N-dimethyl-formamide;
1.1: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2019.02.054
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: thionyl chloride / 1 h / 0 °C
1.2: 4 h / 65 °C
2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 20 °C
With
N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile);
In
tetrachloromethane;
DOI:10.1016/j.ejmech.2019.02.054
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