2,4-Dihydroxy-3-nitropyridine

Base Information

• Chemical Name: 2,4-Dihydroxy-3-nitropyridine
• CAS No.: 89282-12-2
• Molecular Formula: C5H4N2O4
• Molecular Weight: 156.098
• Hs Code.: 29333990
• Mol file: 89282-12-2.mol

Synonyms:3-nitropyridine-2,4-diol;2(1H)-Pyridinone, 4-hydroxy-3-nitro-;

Chemical Property of 2,4-Dihydroxy-3-nitropyridine

Chemical Property:

• Appearance/Colour: light yellow crystalline powder
• Melting Point: 265 °C (dec.)
• Boiling Point: 259.3 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 110.6 °C
• PSA: 99.17000
• Density: 1.65 g/cm³
• LogP: 0.92420
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Nitropyridine-2,4-diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dihydroxy-3-nitropyridine

There total 7 articles about 2,4-Dihydroxy-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-deazauracil (626-03-9,84719-31-3) → 2,4-dihydroxy-3-nitropyridine (89282-12-2)

Guidance literature:

With sulfuric acid; nitric acid; at 0 ℃; Industrial scale;

DOI:10.1021/op400304h

Reference yield: 90.0%

3-deazauracil (626-03-9,84719-31-3) → 4-hydroxy-3-nitro-2(1H)-pyridone (89282-12-2)

Guidance literature:

With nitric acid; at 80 ℃; for 0.25 - 0.333333h;

Reference yield: 60.0%

4,6-dihydroxy-nicotinic acid (5466-62-6) → 2,4-dihydroxy-3-nitropyridine (89282-12-2)

Guidance literature:

With phosphoric acid; nitric acid; acetic acid; In water;

upstream raw materials:

3-deazauracil

MB₂₁₈₃₃

4,6-dihydroxy-nicotinic acid

4,6-dihydroxynicotinic acid ethyl ester

Downstream raw materials:

4-chloro-3-nitropyridin-2(1H)-one

C₁₂H₉ClN₂O₄

C₁₃H₁₁ClN₂O₂

C₁₄H₁₃ClN₂O₂

Refernces

• 1、 -. "1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS". Paragraph 0245. . Retrieved 2017/02/09.
• 2、 Dzierba, Carolyn D.,Sielecki, Thais M.,Arvanitis, Argyrios G.,Galka, Amy,Johnson, Tricia L.,Takvorian, Amy G.,Rafalski, Maria,Kasireddy-Polam, Padmaja,Vig, Shikha,Dasgupta, Bireshwar,Zhang, Ge,Molski, Thaddeus F.,Wong, Harvey,Zaczek, Robert C.,Lodge, Nicholas J.,Combs, Andrew P.,Gilligan, Paul J.,Trainor, George L.,Bronson, Joanne J.,MacOr, John E.. "Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin- 3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists". scheme or table. p. 4986 - 4989. Retrieved 2012/08/28.