3,5-Dimethoxyaniline

Base Information

• Chemical Name: 3,5-Dimethoxyaniline
• CAS No.: 10272-07-8
• Molecular Formula: C8H11NO2
• Molecular Weight: 153.181
• Hs Code.: 29222990
• European Community (EC) Number: 233-616-5
• UNII: JS9DUH84WG
• DSSTox Substance ID: DTXSID0065018
• Nikkaji Number: J175.238C
• Wikidata: Q72467599
• Mol file: 10272-07-8.mol

Synonyms:3,5-Dimethoxyaniline;10272-07-8;Benzenamine, 3,5-dimethoxy-;3,5-Dimethoxybenzeneamine;5-Aminoresorcinol dimethyl ether;3,5-DIMETHOXY-PHENYLAMINE;3,5-DIMETHOXYBENZENAMINE;5-Aminoresorcinol dimethylether;MFCD00008392;JS9DUH84WG;EINECS 233-616-5;3,5-Dimethoxyanaline;3,5-Dimethoxy aniline;3,5-dimethoxylaniline;3,5-dimethoxy analine;3,5-dimethoxy-aniline;3,5 Dimethoxy-aniline;3.5-Dimethoxybenzenamine;UNII-JS9DUH84WG;3,5-dimethoxy-benzenamine;3,5-Dimethoxyaniline, 98%;SCHEMBL116606;DTXSID0065018;CHEBI:172328;CS-B0774;STL168344;AKOS000119595;AC-2497;AS-12377;SY001674;AM20020107;D1484;FT-0620026;EN300-20191;A19805;W-108865;F5608-0063;Z104477210

Chemical Property of 3,5-Dimethoxyaniline

Chemical Property:

• Appearance/Colour: White crystal or Colorless liquid
• Vapor Pressure: 0.000963mmHg at 25°C
• Melting Point: 54-57 ºC
• Refractive Index: 1.54
• Boiling Point: 178 ºC (20 mmHg)
• PKA: pK1:3.86(+1) (25°C)
• Flash Point: 135 ºC
• PSA: 44.48000
• Density: 1.096 g/cm³
• LogP: 1.86720
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: DMSO, Methanol
• Water Solubility.: insoluble
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 153.078978594
• Heavy Atom Count: 11
• Complexity: 107

Purity/Quality:

99% ^*data from raw suppliers

3,5-Dimethoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39-22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)N)OC
• Uses: 3,5-Dimethoxyaniline is a compound useful in organic synthesis. 3,5-Dimethoxyaniline (cas# 10272-07-8) is a compound useful in organic synthesis.

Technology Process of 3,5-Dimethoxyaniline

There total 28 articles about 3,5-Dimethoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-azido-3,5-dimethoxybenzene (85862-68-6) → 3.5-dimethoxyaniline (10272-07-8)

Guidance literature:

With sodium tetrahydroborate; palladium; In water; for 1.5h; Inert atmosphere;

DOI:10.1002/cssc.201900369

Reference yield: 94.0%

N-(3,5-dimethoxyphenyl)-2,2,2-trifluoroacetamide (85657-94-9) → 3.5-dimethoxyaniline (10272-07-8)

Guidance literature:

With water; potassium carbonate; In methanol; for 20h; Ambient temperature;

DOI:10.1055/s-1983-30213

Reference yield: 93.0%

1-chloro-3,5-dimethoxybenzene (7051-16-3) → 3.5-dimethoxyaniline (10272-07-8)

Guidance literature:

With ammonium hydroxide; potassium phosphate; In dimethyl sulfoxide; at 80 ℃; UV-irradiation;

DOI:10.1007/s11426-020-9859-9

upstream raw materials:

1-Bromo-2,4-dimethoxybenzene

1,3-dimethoxy-5-nitrobenzene

3,5-dimethoxybenzamide

N-(3,5-dimethoxy-phenyl)-acetamide

Downstream raw materials:

1-isothiocyanato-3,5-dimethoxybenzene

N-(3,5-bis-(methoxy)phenyl)anthranilic acid

N-(3,5-dimethoxy-phenyl)-acetamide

8-(3,5-dimethoxyphenyl)-8-azabicyclo<3.2.1>octan-3-one

Refernces

• 1、 Pailer,M. et al.. "-". . p. 1603 - 1612. Retrieved 1967.
• 2、 Chen, Dong,Dong, Xinrui,Jiang, Shang,Jiang, Sheng,Qiu, Yatao,Wu, Xiaoxing. "A new ligand for copper-catalyzed amination of aryl halides to primary(hetero)aryl amines". supporting information. . Retrieved 2020/02/11.
• 3、 Lee, Nicholas R.,Cortes-Clerget, Margery,Wood, Alex B.,Lippincott, Daniel J.,Pang, Haobo,Moghadam, Farbod A.,Gallou, Fabrice,Lipshutz, Bruce H.. "Coolade. A Low-Foaming Surfactant for Organic Synthesis in Water". . p. 3159 - 3165. Retrieved 2019/04/26.