N-benzyl-3-(4-benzyl-1-piperidinyl)-1-propaneamine

Base Information

• Chemical Name: N-benzyl-3-(4-benzyl-1-piperidinyl)-1-propaneamine
• CAS No.: 304858-97-7
• Molecular Formula: C₂₂H₃₀N₂
• Molecular Weight: 322.494
• Mol file: 304858-97-7.mol

Synonyms:N-benzyl-3-(4-benzyl-1-piperidinyl)-1-propaneamine

Chemical Property of N-benzyl-3-(4-benzyl-1-piperidinyl)-1-propaneamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-3-(4-benzyl-1-piperidinyl)-1-propaneamine

There total 5 articles about N-benzyl-3-(4-benzyl-1-piperidinyl)-1-propaneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

4-benzyl-1-(3-amino-n-prop-1-yl)piperidine (24157-18-4) + benzaldehyde (100-52-7) → N-benzyl-3-(4-benzyl-1-piperidinyl)-1-propaneamine (304858-97-7)

Guidance literature:

4-benzyl-1-(3-amino-n-prop-1-yl)piperidine; benzaldehyde; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; acetic acid; at 20 ℃; for 14h;

Reference yield: 44.0%

benzylamine (100-46-9) + 3-(4-benzyl-piperidin-1-yl)-propionaldehyde → N-benzyl-3-(4-benzyl-1-piperidinyl)-1-propaneamine (304858-97-7)

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at -10 - 20 ℃;

DOI:10.1248/cpb.52.63

Reference yield:

1N-sodium hydroxide + 4N-hydrogen chloride + 2N-sodium hydroxide + 4-benzylpyperidine (31252-42-3) + acrolein (107-02-8,25068-14-8) + benzylamine (100-46-9) → N-benzyl-3-(4-benzyl-1-piperidinyl)-1-propaneamine (304858-97-7)

Guidance literature:

With sodium tris(acetoxy)borohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; ethyl acetate; isopropyl alcohol;

upstream raw materials:

benzylamine

4-benzyl-1-(3-amino-n-prop-1-yl)piperidine

benzaldehyde

4-benzylpyperidine

Refernces

• 1、 -. "Cyclic amine compounds as CCR5 antagonists". . . Retrieved 2008/06/13.
• 2、 -. "UREA COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF". . . Retrieved 2008/06/13.