Difluoromethane

Base Information

• Chemical Name: Difluoromethane
• CAS No.: 75-10-5
• Molecular Formula: CH2F2
• Molecular Weight: 52.0237
• Hs Code.: 2903399090
• European Community (EC) Number: 200-839-4,606-795-6
• UN Number: 3252
• UNII: 77JW9K722X
• DSSTox Substance ID: DTXSID6029597,DTXSID901045808
• Nikkaji Number: J28.328B
• Wikipedia: Difluoromethane
• Wikidata: Q421742,Q83051817
• Metabolomics Workbench ID: 56815
• ChEMBL ID: CHEMBL115186
• Mol file: 75-10-5.mol

Synonyms:difluoromethane;difluoromethylene;HFC32

Chemical Property of Difluoromethane

Chemical Property:

• Appearance/Colour: colorless odorless gas
• Vapor Pressure: 13200mmHg at 25°C
• Melting Point: -136 °C(lit.)
• Refractive Index: 1.195
• Boiling Point: −51.6°C(lit.)
• PSA: 0.00000
• Density: 0.929 g/cm³
• LogP: 0.88290
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 52.01245639
• Heavy Atom Count: 3
• Complexity: 2.8
• Transport DOT Label: Flammable Gas

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): F
• Hazard Codes: F:Flammable
• Statements: R11:
• Safety Statements: S9:; S16:; S33:

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Solvents -> Chlorofluorocarbons
• Canonical SMILES: C(F)F

Technology Process of Difluoromethane

There total 94 articles about Difluoromethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.9%

dichloromethane (75-09-2) → methylene chloride (74-87-3) + Difluoromethane (75-10-5) + R32 (593-70-4) + trifluoromethan (75-46-7)

Guidance literature:

With hydrogen fluoride; antimony(III) fluoride; antimony pentafluoride; at 5 - 100 ℃; under 12504.7 Torr;

Reference yield: 79.6%

dichloromethane (75-09-2) → Difluoromethane (75-10-5) + R32 (593-70-4)

Guidance literature:

With hydrogen fluoride; chromia-alumina catalyst; at 100 - 400 ℃; for 24h;

dichloromethane; With hydrogen fluoride; at 250 - 275 ℃; Conversion of starting material;

Reference yield: 53.4%

dichloromethane (75-09-2) + ammonia (7664-41-7) → hydrogen cyanide (74-90-8) + Methyl fluoride (593-53-3) + Difluoromethane (75-10-5) + Chlorodifluoromethane (75-45-6) + carbon dioxide (124-38-9,18923-20-1)

Guidance literature:

With catalyst: Pt/C; In neat (no solvent); steady-state flow reaction over Pt/C catalyst at 769 K;

DOI:10.1039/c39900001247

upstream raw materials:

hypofluorous acid trifluoromethyl ester

methane

diiodomethane

dichloromethane

Downstream raw materials:

bromodifluoromethane

Chlorodifluoromethane

Dichlorodifluoromethane

dibromodifluoromethane

Refernces

• 1、 Jacox, M. E.,Milligan, D. E.. "". . p. 3252 - 3262. Retrieved 1969.
• 2、 Chen, Changyun,Lu, Bo,Zhao, Xiaofang,Qian, Weiyu,Liu, Jie,Trabelsi, Tarek,Francisco, Joseph S.,Qin, Jie,Li, Jun,Wang, Lina,Zeng, Xiaoqing. "Capture of the Sulfur Monoxide-Hydroxyl Radical Complex". supporting information. p. 2175 - 2179. Retrieved 2020/03/03.
• 3、 Fu, Xia-Ping,Xiao, Yu-Lan,Zhang, Xingang. "Nickel-Catalyzed Difluoromethylation of Arylboronic Acids with Bromodifluoromethane". supporting information. p. 143 - 146. Retrieved 2018/01/05.