H-Phe-Ala-OBn

Base Information

• Chemical Name: H-Phe-Ala-OBn
• CAS No.: 73393-25-6
• Molecular Formula: C₁₉H₂₂N₂O₃
• Molecular Weight: 326.395
• Mol file: 73393-25-6.mol

Synonyms:H-Phe-Ala-OBn

Chemical Property of H-Phe-Ala-OBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-Phe-Ala-OBn

There total 4 articles about H-Phe-Ala-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-alanine benzyl ester p-toluenesulfonate (42854-62-6) + L-phenylalanine-N-carboxyanhydride (14825-82-2) → H-Phe-Ala-OBn (73393-25-6)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1246/bcsj.54.2705

Reference yield:

Boc-Phe-Ala-OBz (74257-68-4) → H-Phe-Ala-OBn (73393-25-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; Inert atmosphere;

DOI:10.1002/cbic.201300032

Reference yield:

L-alanine benzyl ester p-toluenesulfonate (42854-62-6) → H-Phe-Ala-OBn (73393-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 26 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1002/cbic.201300032

upstream raw materials:

L-alanine benzyl ester p-toluenesulfonate

L-phenylalanine-N-carboxyanhydride

Boc-Phe-Ala-OBz

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

Boc-Leu-Phe-Ala-OBn

N-L-phenylalanyl-L-alanine

Refernces

• 1、 Oya, Masanao,Takahashi, Tomoko. "The Steric Hindrance of the Stepwise Reaction of N-Carboxy α-Amino Acid Anhydride with the α-Amino Acid Ester". . p. 2705 - 2707. Retrieved 2007/10/02.