Ethyl (2-hydroxyphenyl)acetate

Base Information

• Chemical Name: Ethyl (2-hydroxyphenyl)acetate
• CAS No.: 41873-65-8
• Molecular Formula: C10H12 O3
• Molecular Weight: 180.203
• Hs Code.: 2918290000
• European Community (EC) Number: 255-572-6
• UNII: F4552GDG26
• DSSTox Substance ID: DTXSID60194656
• Nikkaji Number: J101.859K
• Wikidata: Q83067447
• ChEMBL ID: CHEMBL483073
• Mol file: 41873-65-8.mol

Synonyms:Ethyl 2-(2-hydroxyphenyl)acetate;41873-65-8;Ethyl (2-hydroxyphenyl)acetate;ETHYL 2-HYDROXYPHENYLACETATE;Benzeneacetic acid, 2-hydroxy-, ethyl ester;2-(2-Hydroxyphenyl)acetic Acid Ethyl Ester;F4552GDG26;EINECS 255-572-6;MFCD09840595;2-Hydroxy-Benzeneacetic Acid Ethyl Ester;UNII-F4552GDG26;CHEMBL483073;SCHEMBL1009146;Ethyl2-(2-hydroxyphenyl)acetate;DTXSID60194656;ETHYL 2-HYDROXYBENZENEACETATE;BBL102404;STL556206;AKOS006237171;2-Hydroxybenzeneacetic acid ethyl ester;s10848;2-hydroxy-phenyl-acetic acid ethyl ester;MS-20433;CS-0141926;FT-0668292;EN300-213896;A872989

Chemical Property of Ethyl (2-hydroxyphenyl)acetate

Chemical Property:

• Vapor Pressure: 0.0026mmHg at 25°C
• Boiling Point: 278°Cat760mmHg
• Flash Point: 115.3°C
• PSA: 46.53000
• Density: 1.146g/cm³
• LogP: 1.49780
• Storage Temp.: -20?C Freezer
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 168

Purity/Quality:

98%Min ^*data from raw suppliers

Ethyl2-Hydroxyphenylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CC1=CC=CC=C1O
• Uses: Ethyl 2-Hydroxyphenylacetate is a useful synthetic intermediate for the preparation of novel antiinflammatory agents.

Technology Process of Ethyl (2-hydroxyphenyl)acetate

There total 8 articles about Ethyl (2-hydroxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethanol (64-17-5) + 2-Hydroxyphenylacetic acid (614-75-5) → ethyl 2-(2-hydroxyphenyl)acetate (41873-65-8)

Guidance literature:

With sulfuric acid; for 4h; Inert atmosphere; Reflux;

DOI:10.1021/ja907568j

Reference yield: 94.0%

→ ethyl 2-(2-hydroxyphenyl)acetate (41873-65-8)

Guidance literature:

Reference yield: 92.0%

ethyl acetate (141-78-6) + 2-Hydroxyphenylacetic acid (614-75-5) → ethyl 2-(2-hydroxyphenyl)acetate (41873-65-8)

Guidance literature:

With sodium hydrogen sulfate; silica gel; at 20 ℃; for 6h;

DOI:10.1055/s-2000-8205

upstream raw materials:

ethanol

2-Hydroxyphenylacetic acid

ethyl acetate

salicylaldehyde

Downstream raw materials:

ethyl 2-(2-((tert-butyldimethylsilyl)oxy)phenyl)acetate

Refernces

• 1、 Huang, Zhusheng,Yang, Xiuqin,Yang, Fulai,Lu, Tao,Zhou, Qingfa. "Phosphine-Catalyzed Domino β/γ-Additions of Benzofuranones with Allenoates: A Method for Unsymmetrical 3,3-Disubstituted Benzofuranones". supporting information. p. 3524 - 3527. Retrieved 2017/07/17.
• 2、 Kang, Byungsoo,Lee, Min Hyung,Kim, Mijung,Hwang, Jungwoon,Kim, Hyeong Baik,Chi, Dae Yoon. "Transition-Metal-Free Synthesis of 2-Substituted Methyl Benzo[b]furan-3-carboxylates". . p. 8254 - 8261. Retrieved 2015/09/01.