2-Methoxypyridin-3-amine

Base Information

• Chemical Name: 2-Methoxypyridin-3-amine
• CAS No.: 20265-38-7
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.142
• Hs Code.: 29339900
• European Community (EC) Number: 673-107-9
• DSSTox Substance ID: DTXSID60372093
• Nikkaji Number: J497.463H
• Wikidata: Q72485719
• ChEMBL ID: CHEMBL3277157
• Mol file: 20265-38-7.mol

Synonyms:2-methoxypyridin-3-amine;20265-38-7;3-amino-2-methoxypyridine;2-methoxy-3-aminopyridine;2-methoxy-pyridin-3-ylamine;MFCD00833386;3-pyridinamine, 2-methoxy-;2-methoxy pyridin-3-amine;2-Methoxy-pyridin-3-amine;2-methoxy-3-amino-pyridine;3-amino-2-methoxy-pyridine;SCHEMBL235146;CHEMBL3277157;2-METHOXY-3-PYRIDINAMINE;DTXSID60372093;2-METHOXYPYRIDINE-3-AMINE;CHEBI:194864;YXFAOWYMDGUFIQ-UHFFFAOYSA-N;BCP22227;2-Methoxy-3-pyridinamine, AldrichCPR;AKOS000113549;AB07386;AC-8287;CS-W008209;PS-5506;SDCCGMLS-0066259.P001;BP-10353;SY009589;A4411;AM20070259;FT-0612868;EN300-42256;J-509873;Z240084308

Chemical Property of 2-Methoxypyridin-3-amine

Chemical Property:

• Vapor Pressure: 0.0377mmHg at 25°C
• Melting Point: 67 °C
• Refractive Index: 1.56
• Boiling Point: 240.5 °C at 760 mmHg
• PKA: 4.33±0.10(Predicted)
• Flash Point: 99.3 °C
• PSA: 48.14000
• Density: 1.139 g/cm³
• LogP: 1.25360
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: soluble in Methanol
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxypyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC=N1)N

Technology Process of 2-Methoxypyridin-3-amine

There total 8 articles about 2-Methoxypyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methoxy-3-nitropyridine (20265-35-4) → 3-amino-2-methoxypyridine (20265-38-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(97)00771-0

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + sodium methylate (124-41-4) → 3-amino-2-methoxypyridine (20265-38-7)

Guidance literature:

2-Chloro-3-nitropyridine; sodium methylate; In methanol; at 0 - 20 ℃; for 3.5h; Inert atmosphere;

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol;

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 3-amino-2-methoxypyridine (20265-38-7)

Guidance literature:

With sodium hydroxide; anschliessendes Hydrieren an Palladium/CaCO₃;

upstream raw materials:

2-chloro-3-aminopyridine

2-Chloro-3-nitropyridine

2-methoxy-3-nitropyridine

2-methoxy-3-pyridinecarboxamide

Downstream raw materials:

2-chloro-N-(1,2-dihydro-2-oxo-3-pyridinyl)benzene acetamide

N-(2-methoxy-3-pyridyl)-2,2-dimethylpropanamide

2-chloro-N-(1,2-dihydro-2-oxo-3-pyridinyl)acetamide

2-chloro-N-(2-methoxy-3-pyridinyl)acetamide

Refernces

• 1、 -. "OREXIN RECEPTOR ANTAGONISTS". Page/Page column 88. . Retrieved 2014/01/18.
• 2、 Jeanty, Matthieu,Blu, Jerome,Suzenet, Franck,Guillaumet, Gerald. "Synthesis of 4- and 6-azaindoles via the fischer reaction". supporting information; experimental part. p. 5142 - 5145. Retrieved 2009/12/28.