3-Hydroxy-2-methylbenzoic acid

Base Information

• Chemical Name: 3-Hydroxy-2-methylbenzoic acid
• CAS No.: 603-80-5
• Molecular Formula: C8H8O3
• Molecular Weight: 152.15
• Hs Code.: 29182900
• Mol file: 603-80-5.mol

Synonyms:NSC73133;2-Methyl-3-hydroxybenzoic acid;3,2-Cresoticacid (8CI);

Chemical Property of 3-Hydroxy-2-methylbenzoic acid

Chemical Property:

• Appearance/Colour: Light yellow crystalline solid
• Vapor Pressure: 4.36E-05mmHg at 25°C
• Melting Point: 143-148 °C
• Boiling Point: 336.6 °C at 760 mmHg
• PKA: 3.83±0.10(Predicted)
• Flash Point: 171.6 °C
• PSA: 57.53000
• Density: 1.304 g/cm³
• LogP: 1.39880
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99.9% ^*data from raw suppliers

3-Hydroxy-2-methylbenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Hydroxy-2-methylbenzoic Acid (cas# 603-80-5) is a compound useful in organic synthesis.

Technology Process of 3-Hydroxy-2-methylbenzoic acid

There total 26 articles about 3-Hydroxy-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-amino-2-methylbenzoic acid (52130-17-3) → 3-hydroxy 2-methylbenzoic acid (603-80-5)

Guidance literature:

3-amino-2-methylbenzoic acid; With sulfuric acid; sodium nitrite; In water; at 7 ℃; for 0.5h;

With sulfuric acid; water; urea; In water; at 90 ℃;

Reference yield: 94.4%

conc. H2 SO4 + diethyl ether (60-29-7,927820-24-4) + sulfuric acid (7664-93-9) + methyl 3-amino-2-methylbenzoate (18583-89-6) → 3-hydroxy 2-methylbenzoic acid (603-80-5)

Guidance literature:

With sodium nitrite; In water; acetic acid;

Reference yield: 79.0%

3-iodo-2-methylbenzoic acid (133232-56-1) → 3-hydroxy 2-methylbenzoic acid (603-80-5)

Guidance literature:

With copper(I) oxide; 1D-1-O-Methyl-muco-inostol; sodium hydroxide; In water; at 100 ℃; for 6h;

upstream raw materials:

1-amino-5-hydroxynaphthalene-7-sulphonic acid

5-amino-naphthalene-1,7-disulfonic acid

naphthalene-1,3,5-trisulphonic acid

3-amino-1,5-naphthalenedisulfonic acid

Downstream raw materials:

ethyl 3-hydroxy-2-methylbenzoate

methyl 3-hydroxy-2-methylbenzoate

KNI-577

ortho-cresol

Refernces

• 1、 Bao, Xuefei,Chen, Guoliang,Dong, Jinhua,Du, Fangyu,Li, Hui,Liang, Xinjie,Wu, Ying,Zhang, Yongsheng. "Copper and L-(?)-quebrachitol catalyzed hydroxylation and amination of aryl halides under air". supporting information. . Retrieved 2020/08/03.
• 2、 -. "Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators". Page column 29. . Retrieved 2010/02/04.