Phosphonic acid, (4-amino-1-hydroxybutylidene)bis-, monosodium salt

Base Information Edit

Chemical Name:Phosphonic acid, (4-amino-1-hydroxybutylidene)bis-, monosodium salt
CAS No.:121268-17-5
Molecular Formula:C4H12NNaO7P2^.3(H2O)
Molecular Weight:271.079
Hs Code.:29310095
NSC Number:758931,722597
NCI Thesaurus Code:C973
RXCUI:203152
Mol file:121268-17-5.mol

Synonyms:4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate;Alendronate;Alendronate Monosodium Salt, Trihydrate;Alendronate Sodium;Aminohydroxybutane Bisphosphonate;Fosamax;MK 217;MK-217;MK217

Suppliers and Price of Phosphonic acid, (4-amino-1-hydroxybutylidene)bis-, monosodium salt

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Alendronate sodium
50mg
$ 339.00

Usbiological
Alendronic Acid, Monosodium Salt, Trihydrate
250mg
$ 326.00

TRC
AlendronicAcidMonosodiumSaltTrihydrate
1g
$ 165.00

TCI Chemical
Alendronate Sodium Trihydrate >97.0%(T)
25g
$ 266.00

TCI Chemical
Alendronate Sodium Trihydrate >97.0%(T)
5g
$ 84.00

Sigma-Aldrich
Alendronate sodium trihydrate ≥97% (NMR), powder
100mg
$ 214.00

Sigma-Aldrich
Sodium alendronate trihydrate European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Sodium alendronate trihydrate European Pharmacopoeia (EP) Reference Standard
y0001727
$ 190.00

Sigma-Aldrich
Alendronate, Sodium Salt
100mg
$ 185.00

Sigma-Aldrich
Alendronate sodium Pharmaceutical Secondary Standard; Certified Reference Material
1g
$ 95.80

Total 228 raw suppliers

Chemical Property of Phosphonic acid, (4-amino-1-hydroxybutylidene)bis-, monosodium salt Edit

Chemical Property:

Appearance/Colour:white crystalline solid
Melting Point:245 °C(lit.)
Boiling Point:616.7 °C at 760 mmHg
Flash Point:326.7 °C
PSA：211.45000
Density:1.857 g/cm³
LogP:-0.32760
Storage Temp.:−20°C
Solubility.:water, double-distilled: 10 mg/mL
Water Solubility.:Soluble in water at 10mg/ml
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:272.00649503
Heavy Atom Count:15
Complexity:257

Purity/Quality:

99% ^*data from raw suppliers

Alendronate sodium ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,Xi
Hazard Codes:Xn,Xi
Statements: 22-36/37/38
Safety Statements: 26-36-60

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN.[Na+]
Recent ClinicalTrials:Effect of Anti-osteoporotic Medications on Nonalcoholic Fatty Liver Disease
Recent EU Clinical Trials:A multi-centre, blinded, randomised, placebo-controlled trial assessing the clinical and cost effectiveness of a 12 month course of oral alendronate (70mg weekly) in patients presenting with avascular necrosis of the hip - Managing Avascular Necrosis Treatments: an Interventional Study (MANTIS)
Uses Alendronate sodium trihydrate is used as a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. A robust inhibitor of bone resorption that induces apoptosis. Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP. A bisphosphonate used as a bone reabsoption inhibitor dopamine receptor agonist, antiParkinsonian Inhibits bone resorption and increases bone density.
Therapeutic Function Antiosteoporotic

Technology Process of Phosphonic acid, (4-amino-1-hydroxybutylidene)bis-, monosodium salt

There total 7 articles about Phosphonic acid, (4-amino-1-hydroxybutylidene)bis-, monosodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 56-12-2
4-amino-n-butyric acid

: 121268-17-5
sodium alendronate

Guidance literature:: 4-amino-n-butyric acid; With phosphonic Acid; methanesulfonic acid; phosphorus trichloride; at 65 ℃;

With water; Reflux;

With sodium hydroxide; In water;
DOI:10.1021/bc400317h

Reference yield: 90.0%

: 183959-44-6
tetraethyl 2-N-phthalimide-1-hydroxybutylidene-1,1-bisphosphonate

: 121268-17-5
sodium alendronate

Guidance literature:: tetraethyl 2-N-phthalimide-1-hydroxybutylidene-1,1-bisphosphonate; With hydrogenchloride; Heating;

With sodium hydroxide; pH=4.3 - 4.4;
DOI:10.1080/10426500108045257