4-AMINO-2-ETHOXY-5-NITRO-BENZOIC ACID

Base Information

• Chemical Name: 4-AMINO-2-ETHOXY-5-NITRO-BENZOIC ACID
• CAS No.: 86718-18-5
• Molecular Formula: C9H10 N2 O5
• Molecular Weight: 226.189
• Hs Code.: 2922509090
• Mol file: 86718-18-5.mol

Synonyms:4-Amino-2-ethoxy-5-nitrobenzoicacid

Chemical Property of 4-AMINO-2-ETHOXY-5-NITRO-BENZOIC ACID

Chemical Property:

• Vapor Pressure: 2.52E-09mmHg at 25°C
• Melting Point: >208°C (dec.)
• Boiling Point: 461.8°C at 760 mmHg
• Flash Point: 233.1°C
• PSA: 118.37000
• Density: 1.444g/cm³
• LogP: 2.37830
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

4-Amino-2-ethoxy-5-nitrobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Amino-2-ethoxy-5-nitrobenzoic Acid is a reactant used in the preparation Cinitapride (C441990).

Technology Process of 4-AMINO-2-ETHOXY-5-NITRO-BENZOIC ACID

There total 4 articles about 4-AMINO-2-ETHOXY-5-NITRO-BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethoxy-4-nitrobenzoic acid (2486-66-0) → 2-ethoxy-4-amino-5-nitro-benzoic acid (86718-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium nitrate; sulfuric acid / 0 °C

2: aqueous ammonia

With ammonium hydroxide; sulfuric acid; potassium nitrate;

DOI:10.1002/hlca.19490320714

Reference yield:

methyl 4-amino-2-ethoxy-5-nitrobenzoate (86718-17-4) → 2-ethoxy-4-amino-5-nitro-benzoic acid (86718-18-5)

Guidance literature:

With sodium hydroxide; In water; acetic acid;

Reference yield:

2-ethoxy-4,5-dinitro-benzoic acid (408328-89-2) → 2-ethoxy-4-amino-5-nitro-benzoic acid (86718-18-5)

Guidance literature:

With ammonium hydroxide;

DOI:10.1002/hlca.19490320714

upstream raw materials:

2-ethoxy-4,5-dinitro-benzoic acid

2-ethoxy-1-methyl-4-nitrobenzene

2-ethoxy-4-nitrobenzoic acid

methyl 4-amino-2-ethoxy-5-nitrobenzoate

Refernces