3-Chloro-2-nitropyridine

Base Information

• Chemical Name: 3-Chloro-2-nitropyridine
• CAS No.: 54231-32-2
• Molecular Formula: C5H3ClN2O2
• Molecular Weight: 158.544
• Hs Code.: 2933399090
• Mol file: 54231-32-2.mol

Synonyms:3-Chloro-2-nitropyridine;

Chemical Property of 3-Chloro-2-nitropyridine

Chemical Property:

• Appearance/Colour: white to pale yellow solid
• Vapor Pressure: 0.00696mmHg at 25°C
• Melting Point: 90-91°C
• Refractive Index: 1.587
• Boiling Point: 279.051 °C at 760 mmHg
• PKA: -4.87±0.22(Predicted)
• Flash Point: 122.566 °C
• PSA: 58.71000
• Density: 1.489 g/cm³
• LogP: 2.16640
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-2-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38-41-25
• Safety Statements: 26-36/37/39-36-45-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-2-nitropyridine

There total 2 articles about 3-Chloro-2-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

3-amino-2-nitropyridine (13269-19-7) → 3-chloro-2-nitropyridine (54231-32-2)

Guidance literature:

3-amino-2-nitropyridine; With tert.-butylnitrite; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; Flow reactor;

With copper dichloride; In ethylene glycol; N,N-dimethyl-formamide; acetonitrile; at 82 ℃; Flow reactor;

DOI:10.1021/acs.oprd.6b00318

Reference yield:

→ 3-chloro-2-nitropyridine (54231-32-2)

Guidance literature:

DOI:10.1007/BF00480925

Reference yield: 84.1%

3-chloro-2-nitropyridine (54231-32-2) + methyl 4-mercaptobenzoate (6302-65-4) → methyl 4-(2-nitropyridin-3-ylthio)benzoate (953045-58-4)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 1.5h;

upstream raw materials:

3-amino-2-nitropyridine

Downstream raw materials:

4-(3-chloropyridin-2-yl)morpholine

(3-chloro-2-pyridyl)hydrazine

3-nitro-2-(piperidin-1-yl)pyridine

3-chloro-2-(piperidin-1-yl)pyridine

Refernces

• 1、 -. "Nitro, amino and aroylamino-N-phenylpyridinamines in a process for preparing pyrido[1,4]benzodiazepines". . . Retrieved 2008/06/13.