5,6-Diaminouracil

Base Information

• Chemical Name: 5,6-Diaminouracil
• CAS No.: 3240-72-0
• Deprecated CAS: 13034-83-8,23899-74-3,51171-03-0,23899-74-3,51171-03-0
• Molecular Formula: C4H6 N4 O2
• Molecular Weight: 142.117
• Hs Code.: 2933599090
• European Community (EC) Number: 221-809-7
• UNII: VEU0FRO9FL
• DSSTox Substance ID: DTXSID9062930
• Nikkaji Number: J80.671D
• Wikidata: Q27094704
• Metabolomics Workbench ID: 148312
• ChEMBL ID: CHEMBL34076
• Mol file: 3240-72-0.mol

Synonyms:5,6-diamino-2,4-dihydroxypyrimidine;5,6-diamino-2,4-dihydroxypyrimidine sulfate (1:1);5,6-diamino-2,4-dihydroxypyrimidine sulfate (2:1);5,6-diaminouracil

Chemical Property of 5,6-Diaminouracil

Chemical Property:

• Vapor Pressure: 1.59E-25mmHg at 25°C
• Melting Point: >250ºC
• Boiling Point: 778.7ºC at 760 mmHg
• PKA: 4.00±0.10(Predicted)
• Flash Point: 424.7ºC
• PSA: 117.76000
• Density: 1.481±0.06 g/cm3(Predicted)
• LogP: 0.19200
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Water (Slightly)
• XLogP3: -1.9
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 142.04907545
• Heavy Atom Count: 10
• Complexity: 231

Purity/Quality:

99% ^*data from raw suppliers

5,6-Diamino-2,4-dihydroxypyrimidine, Hydrochloride Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Biological Agents -> Nucleic Acids and Derivatives
• Canonical SMILES: C1(=C(NC(=O)NC1=O)N)N

Technology Process of 5,6-Diaminouracil

There total 16 articles about 5,6-Diaminouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-amino-5-nitrosouracil (5442-24-0) → 5,6-diaminouracil (3240-72-0)

Guidance literature:

With diammonium sulfide; at 70 - 80 ℃; for 0.25h;

DOI:10.3184/174751916X14798125870610

Reference yield:

6-amino-1,3-di-n-butyl-5-nitroso-uracil (132716-86-0) → 5,6-diaminouracil (3240-72-0)

Guidance literature:

palladium-carbon; In N,N-dimethyl-formamide;

Reference yield:

alloxan-4,5-dioxime → 5,6-diaminouracil (3240-72-0)

Guidance literature:

With diammonium sulfide; water;

DOI:10.1073/pnas.18.7.490

upstream raw materials:

6-amino-pyrimidine-2,4,5-trione-5-oxime

5-acetylamino-6-amino-1H-pyrimidine-2,4-dione

5,6-bis-acetylamino-1H-pyrimidine-2,4-dione

6-acetylamino-5-(diacetylamino)-pyrimidine-2,4<1H,3H>dione

Downstream raw materials:

6-Methyl-7-oxo-7,8-dihydrolumazin

N-{4-[(2,4-dioxo-1,2,3,4-tetrahydro-pteridin-6-ylmethyl)-amino]-benzoyl}-L-glutamic acid

6-benzyl-1H,8H-pteridine-2,4,7-trione

5,8-dihydro-1H-pteridine-2,4,6,7-tetraone

Refernces

• 1、 Elkalyoubi, Samar,Fayed, Eman. "Synthesis and evaluation of antitumour activities of novel fused tri-And tetracyclic uracil derivatives". . p. 771 - 777. Retrieved 2017/01/03.
• 2、 -. "PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS". . . Retrieved 2010/03/02.