Protirelina

Base Information

• Chemical Name: Protirelina
• CAS No.: 11096-37-0
• Molecular Formula: Unspecified
• Molecular Weight: 362.38368
• Hs Code.: 3002120000
• NSC Number: 760113
• DSSTox Substance ID: DTXSID30860316
• Nikkaji Number: J707.434D
• RXCUI: 4952
• Mol file: 11096-37-0.mol

Synonyms:beta 1 Metal Binding Globulin;beta 2 Transferrin;beta 2-Transferrin;beta-1 Metal-Binding Globulin;Globulin, beta-1 Metal-Binding;Isotransferrin;Metal-Binding Globulin, beta-1;Monoferric Transferrins;Serotransferrin;Siderophilin;tau Transferrin;tau-Transferrin;Transferrin;Transferrin B;Transferrin C;Transferrins, Monoferric

Chemical Property of Protirelina

Chemical Property:

• Appearance/Colour: powder
• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: 2-8°C
• Solubility.: H2O: 50 mg/mL
• Water Solubility.: Soluble in water (50 mg/ml).
• XLogP3: -2.5
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 362.17025320
• Heavy Atom Count: 26
• Complexity: 597

Purity/Quality:

98%, ^*data from raw suppliers

Transferrin, Human ^*data from reagent suppliers

Safty Information:

• Pictogram(s): BXi
• Hazard Codes: B,Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: UVCB,Biological Agents -> Proteins
• Canonical SMILES: C1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=O)N
• Recent EU Clinical Trials: Efficacy of a selective MEK (trametinib) and BRAFV600E (dabrafenib) inhibitors associated with radioactive iodine (RAI) for the treatment of refractory metastatic differentiated thyroid cancer with RAS or BRAFV600E mutation
• Description: Holo-transferrin is the transferrin of the holo iron. It is a kind of iron-binding blood plasmaglycoproteins that is capable of regulating the level of free iron (Fe) in biological fluids. It is responsible for iron transportation in vertebrate serum and donating irons to cells through interaction with the CD71 membrane receptor. Transferrin is crucial for proliferating cells as a growth factor to initiate and maintain the DNA synthesis. It can also act as a cytokine. It is mainly synthesized in liver inside the human body. It is responsible to deliver iron from duodenum and white blood cells macrophages to all the other tissues, and is a key protein to maintain in vivo iron homeostasis. Increased plasma transferrin level is related to diseases such as iron deficiency anemia while decrease plasma transferrin is related to iron overload diseases and protein malnutrition.
• Uses: Transferrin (Holo) is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. It is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. It can be used with a wide range of cells types. It is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media. It has been used for study in treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron. Transferrin is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. Transferrin is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. Human holo-transferrin is a high affinity transferrin that can be used with a wide range of cells types. Human holo-transferrin is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media. All cells require iron for the proper uptake of oxygen from their environment. Transferrin, a protein isolated from serum, causes the uptake and transport of iron from culture medium to the cells. This allows proper oxygen uptake and also stimulates growth-related enzyme activity. Iron-saturated transferrin (holo transferrin) is continually recycled after releasing iron and becomes iron-deficient transferrin (apo-transferrin). Choosing which form to use depends upon the culture conditions. In media such as Dulbecco′s Modified Eagle′s Medium/Ham′s Nutrient Mixture F12 (DMEM/F12) that contain high levels of iron salt, using apo-transferrin is preferred.