FEXOFENADINE HYDROCHLORIDE

Base Information Edit

Chemical Name:FEXOFENADINE HYDROCHLORIDE
CAS No.:138452-21-8
Molecular Formula:C32H40ClNO4
Molecular Weight:538.127
Hs Code.:2942000000
Mol file:138452-21-8.mol

Synonyms:2-[4-[1-Hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride;Allegra;

Suppliers and Price of FEXOFENADINE HYDROCHLORIDE

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Fexofenadine HCl Pharmaceutical Secondary Standard; Certified Reference Material
1 g
$ 192.00

Medical Isotopes, Inc.
Fexofenadine HCl
100 mg
$ 850.00

Total 38 raw suppliers

Chemical Property of FEXOFENADINE HYDROCHLORIDE Edit

Chemical Property:

Appearance/Colour:White solid
Melting Point:195.0 - 199.0oC
Boiling Point:697.3 °C at 760 mmHg
Flash Point:375.5 °C
PSA：81.00000
LogP:6.25040
Storage Temp.:−20°C
Solubility.:DMSO: 32 mg/mL, soluble
Water Solubility.:DMSO: 32 mg/mL, soluble

Purity/Quality:

99%, ^*data from raw suppliers

Fexofenadine HCl Pharmaceutical Secondary Standard; Certified Reference Material ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description The metabolite of seldane (terfenadine), fexofenadine, was launched in the USA. A histamine H1 receptor antagonist, fexofenadine is more effect than its parent compound without the associated side-effects.
Uses Anti-histamine Fexofenadine HCl (Allegra) is a selective, specific H1 antagonist that is structurally related to the butyrophenone tranquilizer haloperidol. It is the active carboxylic acid metabolite of terfenadine (no longer commercially available in the United States). It binds mainly to the peripheral H1 receptors, with minimal crossing of the blood–brain barrier and hence minimal sedative effects. Fexofenadine lacks the cardiotoxic effects of its parent drug, terfenadine. However, it has been associated with increased QT interval, syncope, and ventricular arrhythmia in at least one susceptible patient with preexisting cardiovascular risk. To date, no significant interactions have been demonstrated with fexofenadine when administered concomitantly with azole antifungals or macrolide antibiotics. Indicated for seasonal allergic rhinitis and chronic idiopathic urticaria.

Technology Process of FEXOFENADINE HYDROCHLORIDE

There total 33 articles about FEXOFENADINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 76812-02-7
4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid ethyl ester

: 138452-21-8,153439-40-8
fexofenadine hydrochloride

Guidance literature:: 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid ethyl ester; With sodium hydroxide; In methanol; water; for 2.25h; Heating / reflux;

With sodium tetrahydroborate; In methanol; water; at 20 - 35 ℃; for 49.44h;

With hydrogenchloride; In methanol; water; acetone; at -12 ℃; for 1.41667h;

Reference yield: 91.5%

: 76811-96-6
4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid, ethyl ester hydrochloride

: 138452-21-8,153439-40-8
fexofenadine hydrochloride

Guidance literature:: 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid, ethyl ester hydrochloride; With sodium hydroxide; In methanol; water; at 73 ℃; for 1.75h;

With sodium tetrahydroborate; In methanol; water; at 35 ℃;

With hydrogenchloride; In methanol; water; acetone; at -15 ℃; for 2.5h;