1-[2-(4-Fluorophenyl)ethyl]piperazine

Base Information

• Chemical Name: 1-[2-(4-Fluorophenyl)ethyl]piperazine
• CAS No.: 70931-33-8
• Molecular Formula: C12H17 F N2
• Molecular Weight: 208.279
• Hs Code.: 2933599090
• Mol file: 70931-33-8.mol

Synonyms:1-(4-Fluorophenethyl)piperazine;1-[2-(4-Fluorophenyl)ethyl]piperazine

Chemical Property of 1-[2-(4-Fluorophenyl)ethyl]piperazine

Chemical Property:

• Vapor Pressure: 0.000994mmHg at 25°C
• Boiling Point: 302 ºC
• Flash Point: 137 ºC
• PSA: 15.27000
• Density: 1.062
• LogP: 1.54010

Purity/Quality:

98%min ^*data from raw suppliers

1-[2-(4-fluorophenyl)ethyl]piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[2-(4-Fluorophenyl)ethyl]piperazine

There total 6 articles about 1-[2-(4-Fluorophenyl)ethyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-benzyl-N'-[2-(4-fluorophenyl)ethyl]piperazine → 1-[2-(4-fluorophenyl)-ethyl]-piperazine (70931-33-8)

Guidance literature:

With hydrogen; triethylamine; palladium dihydroxide; In ethanol; at 40 ℃; for 7h; under 1500.15 - 3000.3 Torr;

DOI:10.1002/chem.200305327

Reference yield: 60.0%

1-ethoxycarbonyl-4-<2-(4-fluorophenyl)ethyl>piperazine (70931-36-1) → 1-[2-(4-fluorophenyl)-ethyl]-piperazine (70931-33-8)

Guidance literature:

With potassium hydroxide; In ethanol; at 120 ℃; for 3h;

DOI:10.1135/cccc19803182

Reference yield:

para-fluorostyrene (405-99-2) → 1-[2-(4-fluorophenyl)-ethyl]-piperazine (70931-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran; hexane / 0.17 h / 20 °C

1.2: 87 percent / tetrahydrofuran; hexane / 24 h / 20 °C

2.1: 95 percent / H₂; Et₃N / Pd(OH)2/C / ethanol / 7 h / 40 °C / 1500.15 - 3000.3 Torr

With hydrogen; triethylamine; palladium dihydroxide; In tetrahydrofuran; ethanol; hexane;

DOI:10.1002/chem.200305327

upstream raw materials:

1-ethoxycarbonyl-4-<2-(4-fluorophenyl)ethyl>piperazine

para-fluorostyrene

(2-bromoethyl)-4-fluorobenzene

piperazine

Downstream raw materials:

N-[3-(4-chloro-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl]-4-(4-fluorophenethyl)piperazine-1-carboxamide

N-(4-bromo-1H-pyrazol-3-yl)-4-(4-fluorophenethyl)piperazine-1-carboxamide

Refernces

• 1、 -. "METHOD FOR THE PRODUCTION OF MONOSUBSTITUTED PIPERAZINE DERIVATIVES". Page/Page column 7-8. . Retrieved 2008/06/13.
• 2、 -. "Disubstituted piperazines". . . Retrieved 2008/06/13.