1-(2,2-difluoro-2-deoxy-β-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one p-toluenesulfonic acid co-crystal

Base Information

• Chemical Name: 1-(2,2-difluoro-2-deoxy-β-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one p-toluenesulfonic acid co-crystal
• CAS No.: 960397-74-4
• Molecular Formula: C₇H₈O₃S*C₁₇H₂₅F₂N₃O₅
• Molecular Weight: 561.604
• Mol file: 960397-74-4.mol

Synonyms:1-(2,2-difluoro-2-deoxy-β-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one p-toluenesulfonic acid co-crystal

Chemical Property of 1-(2,2-difluoro-2-deoxy-β-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one p-toluenesulfonic acid co-crystal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,2-difluoro-2-deoxy-β-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one p-toluenesulfonic acid co-crystal

There total 3 articles about 1-(2,2-difluoro-2-deoxy-β-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one p-toluenesulfonic acid co-crystal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide (892128-60-8) + toluene-4-sulfonic acid (104-15-4) → 1-(2,2-difluoro-2-deoxy-β-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one p-toluenesulfonic acid co-crystal (960397-74-4)

Guidance literature:

In Isopropyl acetate; at 20 ℃; for 0.166667h;

Reference yield:

C11H18N2O2 → 1-(2,2-difluoro-2-deoxy-β-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one p-toluenesulfonic acid co-crystal (960397-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane / pyridine / 2 h / 0 °C

1.2: 0 - 45 °C

1.3: 0 - 45 °C

2.1: Isopropyl acetate / 0.17 h / 20 °C

With chloro-trimethyl-silane; In pyridine; Isopropyl acetate;

Reference yield:

valproic acid (99-66-1) → 1-(2,2-difluoro-2-deoxy-β-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one p-toluenesulfonic acid co-crystal (960397-74-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane / acetonitrile / 2.5 h

1.3: 0 - 45 °C

2.1: chloro-trimethyl-silane / pyridine / 2 h / 0 °C

2.2: 0 - 45 °C

2.3: 0 - 45 °C

3.1: Isopropyl acetate / 0.17 h / 20 °C

With chloro-trimethyl-silane; In pyridine; Isopropyl acetate; acetonitrile;

upstream raw materials:

N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide

toluene-4-sulfonic acid

valproic acid

Refernces