2-Aminocarbonyl-3-nitrobenzoic acid

Base Information

• Chemical Name: 2-Aminocarbonyl-3-nitrobenzoic acid
• CAS No.: 77326-45-5
• Molecular Formula: C8H6N2O5
• Molecular Weight: 210.146
• Hs Code.: 2924299090
• Mol file: 77326-45-5.mol

Synonyms:2-(Aminocarbonyl)-3-nitrobenzoicacid;3-Nitrophthalamic acid;NSC 519708;

Chemical Property of 2-Aminocarbonyl-3-nitrobenzoic acid

Chemical Property:

• Vapor Pressure: 4.57E-07mmHg at 25°C
• Refractive Index: 1.655
• Boiling Point: 398.5 °C at 760 mmHg
• Flash Point: 194.8 °C
• PSA: 126.21000
• Density: 1.585 g/cm³
• LogP: 1.61540
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Carbamoyl-3-nitrobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Aminocarbonyl-3-nitrobenzoic acid

There total 4 articles about 2-Aminocarbonyl-3-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-nitro-phthalamic acid ; ammonium compound → 2-carbamoyl-3-nitrobenzoic acid (77326-45-5)

Guidance literature:

With hydrogenchloride; In water; at 38 - 55 ℃;

Reference yield: 96.0%

3-nitrophthalic acid anhydride (641-70-3) → 2-carbamoyl-3-nitrobenzoic acid (77326-45-5)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/ddr.21843

Reference yield: 90.0%

4-nitro-1H-isoindole-1,3(2H)-dione (603-62-3) → 2-carbamoyl-3-nitrobenzoic acid (77326-45-5)

Guidance literature:

4-nitro-1H-isoindole-1,3(2H)-dione; With potassium hydroxide; water; at 0 - 30 ℃; for 6h;

With hydrogenchloride; water; at 0 ℃; for 1h;

upstream raw materials:

3-nitrophthalic acid anhydride

4-nitro-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

3-nitroanthranilic acid

6-nitroanthranilic acid

1H-benzo[d]imidazole-4-carbaldehyde

(1H-benzo[d]imidazol-4-yl)methanol

Refernces

• 1、 -. "Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor". Page/Page column 66; 67. . Retrieved 2016/09/26.
• 2、 -. "COMPOSITIONS AND METHODS FOR INDUCING CONFORMATIONAL CHANGES IN CEREBLON OTHER E3 UBIQUITIN LIGASES". Paragraph 00374. . Retrieved 2016/05/02.