4-METHYLPHENETHYL BROMIDE 97

Base Information

• Chemical Name: 4-METHYLPHENETHYL BROMIDE 97
• CAS No.: 6529-51-7
• Molecular Formula: C9H11Br
• Molecular Weight: 199.09
• Hs Code.: 2903999090
• Mol file: 6529-51-7.mol

Synonyms:Toluene,p-(2-bromoethyl)- (6CI,7CI,8CI);1-(2-Bromoethyl)-4-methylbenzene;1-Bromo-2-(4-methylphenyl)ethane;1-Bromo-2-p-tolylethane;4-Methylphenethylbromide;p-(2-Bromoethyl)toluene;p-Methyl-b-bromoethylbenzene;p-Methylphenethyl bromide;

Chemical Property of 4-METHYLPHENETHYL BROMIDE 97

Chemical Property:

• Refractive Index: n20/D 1.550
• Boiling Point: 226 °C at 760 mmHg
• Flash Point: 94.8 °C
• PSA: 0.00000
• Density: 1.312 g/cm³
• LogP: 2.93240
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methylphenethyl bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-37/38-41-51/53
• Safety Statements: 26-39-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYLPHENETHYL BROMIDE 97

There total 10 articles about 4-METHYLPHENETHYL BROMIDE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-Methylphenethyl alcohol (699-02-5) → 2-(4-methylphenyl)ethyl bromide (6529-51-7)

Guidance literature:

With phosphorus tribromide; at 0 - 100 ℃; for 17h;

DOI:10.1021/ol901724v

Reference yield:

4-tolylacetic acid (622-47-9) → 2-(4-methylphenyl)ethyl bromide (6529-51-7)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄

2: PBr₃

With lithium aluminium tetrahydride; phosphorus tribromide;

DOI:10.1016/S0957-4166(98)00277-8

Reference yield:

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) → 2-(4-methylphenyl)ethyl bromide (6529-51-7) + 1-(1-bromoethyl)-4-methylbenzene (159755-12-1)

Guidance literature:

With hydrogen bromide; acetic acid; In hexane; at 0 ℃; for 2h; Overall yield = 91 %;

DOI:10.1039/c6ob00692b

upstream raw materials:

4-Methylphenethyl alcohol

1-Adamantyl bromide

4-tolylacetic acid

para-bromotoluene

Downstream raw materials:

methyl(4-methylphenethyl)sulfane

1-ethenyl-4-methylbenzene

dibutyl-(4-methyl-phenethyl)-amine

N,N-diethyl-2-(4-methylphenyl)-ethanamine

Refernces

• 1、 Galli, Marzia,Fletcher, Catherine J.,Del Pozo, Marc,Goldup, Stephen M.. "Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins". supporting information. p. 5622 - 5626. Retrieved 2016/07/06.
• 2、 -. "2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF". Page/Page column 36. . Retrieved 2010/02/08.