5-Bromoquinoxalin-6-amine

Base Information

• Chemical Name: 5-Bromoquinoxalin-6-amine
• CAS No.: 50358-63-9
• Molecular Formula: C8H6BrN3
• Molecular Weight: 224.06
• Hs Code.: 29339900
• Mol file: 50358-63-9.mol

Synonyms:5-Bromo-6-aminoquinoxaline;6-Amino-5-bromoquinoxaline;5-Bromo-6-quinoxalinamine;

Chemical Property of 5-Bromoquinoxalin-6-amine

Chemical Property:

• Appearance/Colour: yellow solid
• Vapor Pressure: 1.4E-05mmHg at 25°C
• Melting Point: 151-153 °C
• Refractive Index: 1.747
• Boiling Point: 367 °C at 760 mmHg
• PKA: 0.33±0.30(Predicted)
• Flash Point: 175.8 °C
• PSA: 51.80000
• Density: 1.744 g/cm³
• LogP: 2.55570
• Storage Temp.: Refrigerator

Purity/Quality:

99% ^*data from raw suppliers

6-Amino-5-bromoquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Brimonidine. Antiglaucoma agent (brimonidine tartrate ophthalmic solution) 0.15%

Technology Process of 5-Bromoquinoxalin-6-amine

There total 6 articles about 5-Bromoquinoxalin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

6-aminoquinoxaline (6298-37-9) → 5-bromo-6-amino-quinoxaline (50358-63-9)

Guidance literature:

With hydrogen bromide; oxygen; copper(ll) bromide; In water; at 90 - 95 ℃; for 4h; under 760.051 Torr; Reagent/catalyst; Temperature; Solvent;

Reference yield: 97.0%

5-bromo-6-nitroquinoxaline → 5-bromo-6-amino-quinoxaline (50358-63-9)

Guidance literature:

With C₃₆H₅₆Cl₃CrN₂O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 60 ℃; for 24h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/jacs.0c12318

Reference yield:

6-aminoquinoxaline (6298-37-9) → 6-amino-5-bromo-quinoxaline hydrobromide (134892-45-8) + 5-bromo-6-amino-quinoxaline (50358-63-9)

Guidance literature:

With bromine; In water; acetic acid;

upstream raw materials:

6-aminoquinoxaline

6-nitroquinoxaline

4-Nitrophenylene-1,2-diamine

Refernces

• 1、 Zhao, Lixing,Hu, Chenyang,Cong, Xuefeng,Deng, Gongda,Liu, Liu Leo,Luo, Meiming,Zeng, Xiaoming. "Cyclic (Alkyl)(amino)carbene Ligand-Promoted Nitro Deoxygenative Hydroboration with Chromium Catalysis: Scope, Mechanism, and Applications". supporting information. p. 1618 - 1629. Retrieved 2021/01/25.
• 2、 -. "Methods of preventing and reducing the severity of stress-associated conditions". . . Retrieved 2008/06/13.