(R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid

Base Information Edit

Chemical Name:(R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid
CAS No.:170080-13-4
Molecular Formula:C₁₅H₁₅NO₂
Molecular Weight:241.29
Hs Code.:
DSSTox Substance ID:DTXSID50426534
Nikkaji Number:J2.437.550A
Mol file:170080-13-4.mol

Synonyms:170080-13-4;(R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid;D-4,4'-Biphenylalanine;H-4-PHENYL-D-PHE-OH;(2R)-2-amino-3-(4-phenylphenyl)propanoic acid;D-BIPHENYLALANINE;4-Phenyl-D-Phenylalanine;(R)-2-amino-3-(biphenyl-4-yl)propanoic acid;3-(4-Biphenylyl)-D-alanine;D-4,4'-BIPHENYLPHENYLALANINE;H-D-BIP-OH;MFCD01318879;4-Phenyl-L-phenyalanine;4'-BIPHENYL-D-ALA;(R)-2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID;SCHEMBL1796036;[1,1'-Biphenyl]-4-propanoic acid,alpha-amino-,(alphaR)-;DTXSID50426534;BCP15269;CS-M2870;AM9195;AKOS016843305;AC-9868;D-4,4'-Biphenylalanine (H-D-Bip-OH);DS-16373;HY-79107;H--(4-Biphenylyl)-D-Ala-OH;H-D-Bip-OH;(2R)-2-Amino-3-(4-biphenylyl)propanoic acid;A882055;[1,1'-Biphenyl]-4-propanoic acid, a-amino-, (R)-;(R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoicacid;(2R)-2-Amino-3-([1,1'-biphenyl]-4-yl)propanoic acid (non-preferred name)

Suppliers and Price of (R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
D-4,4''-Biphenylalanine
100mg
$ 45.00

Labseeker
(R)-2-AMINO-3-BIPHENYL-4-YL-PROPIONICACID 95
1kg
$ 3675.00

Iris Biotech GmbH
H-D-Bip-OH
5 g
$ 1512.00

Iris Biotech GmbH
H-D-Bip-OH
1 g
$ 445.50

ChemScene
D-Biphenylalanine
5g
$ 155.00

ChemScene
D-Biphenylalanine
25g
$ 506.00

chempep
H-D-4,4'-Biphe-OH
5g
$ 530.00

chempep
H-D-4,4'-Biphe-OH
25g
$ 1590.00

Chem-Impex
H-p-Phenyl-D-phenylalanine,≥98%(TLC) ≥98%(TLC)
10G
$ 1145.00

Chem-Impex
H-p-Phenyl-D-phenylalanine,98%(TLC) 98%(TLC)
5G
$ 614.88

Total 63 raw suppliers

Chemical Property of (R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid Edit

Chemical Property:

Boiling Point:428.6 °C at 760 mmHg
PKA:2.21±0.10(Predicted)
Flash Point:213 °C
PSA：63.32000
Density:1.19 g/cm³
LogP:3.00830
Storage Temp.:Store at RT.
Water Solubility.:Slightly soluble in water.
XLogP3:0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:241.110278721
Heavy Atom Count:18
Complexity:266

Purity/Quality:

98%,99%, ^*data from raw suppliers

D-4,4''-Biphenylalanine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC=C(C=C2)CC(C(=O)O)N
Isomeric SMILES:C1=CC=C(C=C1)C2=CC=C(C=C2)C[C@H](C(=O)O)N
Uses It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Technology Process of (R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid

There total 33 articles about (R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.7%

: (R)-N-acetylbiphenylalanine ethyl ester

: 170080-13-4
([1,1’-biphenyl]-4-yl)alanine

Guidance literature:: With hydrogenchloride; In water; Reflux;

Reference yield: 90.0%

: 1446104-51-3
(R)-2-benzoylamino-3-biphenyl-4-yl-propionic acid methyl ester

: 170080-13-4
([1,1’-biphenyl]-4-yl)alanine

Guidance literature:: With sulfuric acid; In water; Reflux;

Reference yield: 48.0%

: 24250-84-8
H-p-BrPhe-OH

: 98-80-6
phenylboronic acid

: 155760-02-4,170080-13-4
(S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In water; isopropyl alcohol; at 80 ℃; for 4h; Sealed tube;
DOI:10.1002/cctc.201500190