Technology Process of (14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine
There total 2 articles about (14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(14bR)-2-[(1'S)-1'-phenylethyl]-1,2,10,14b-tetrahydrodibenzo[c,f]pyrazino[1,2-a]azepine-3,4-dione;
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
for 4h;
Heating;
With
hydrogenchloride;
In
water;
for 2h;
Heating;
DOI:10.1016/S0957-4166(03)00582-2
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine / CH2Cl2 / 24 h / -78 °C
2.1: Me2S*BH3 / tetrahydrofuran / 4 h / Heating
2.2: 94 percent / HCl / H2O / 2 h / Heating
With
pyridine; dimethylsulfide borane complex;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(03)00582-2
- Guidance literature:
-
(14bR)-2-[(1'S)-1'-phenylethyl]-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine;
With
hydrogenchloride; hydrogen;
palladium on activated charcoal;
In
ethanol; water;
for 3h;
atmospheric pressure;
formaldehyd;
In
ethanol; water;
at 10 ℃;
With
sodium tetrahydroborate;
In
ethanol; water;
Title compound not separated from byproducts;
DOI:10.1016/S0957-4166(03)00582-2