Ethyl 3-Iodo-5-Methoxybenzoate

Base Information

• Chemical Name: Ethyl 3-Iodo-5-Methoxybenzoate
• CAS No.: 717109-27-8
• Molecular Formula: C9H9 I O3
• Molecular Weight: 292.073
• Mol file: 717109-27-8.mol

Synonyms:ethyl 3-iodo-5-methoxybenzoate

Chemical Property of Ethyl 3-Iodo-5-Methoxybenzoate

Chemical Property:

• Refractive Index: 1.569
• PSA: 35.53000
• Density: 1.684
• LogP: 2.08640
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Ethyl3-iodo-5-methoxybenzoate 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-Iodo-5-Methoxybenzoate

There total 2 articles about Ethyl 3-Iodo-5-Methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

methyl 3-amino-5-methoxybenzoate (217314-47-1) → methyl 3-iodo-5-methoxybenzoate (717109-27-8)

Guidance literature:

methyl 5-amino-3-methoxybenzoate; With sulfuric acid; sodium nitrite; In water; at -5 ℃; for 0.5h;

With potassium iodide; In water; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b01483

Reference yield:

3-amino-5-methoxybenzoic acid (74165-74-5) → methyl 3-iodo-5-methoxybenzoate (717109-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 80 °C / Cooling with ice; Inert atmosphere

2.1: sodium nitrite; sulfuric acid / water / 0.5 h / -5 °C

2.2: 20 °C

With thionyl chloride; sulfuric acid; sodium nitrite; In water;

DOI:10.1021/acs.jmedchem.8b01483

Reference yield: 99.0%

methyl 3-iodo-5-methoxybenzoate (717109-27-8) → 3-iodo-5-methoxybenzoic acid (74440-82-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b01483

upstream raw materials:

methyl 3-amino-5-methoxybenzoate

3-amino-5-methoxybenzoic acid

Downstream raw materials:

3-iodo-5-methoxybenzoic acid

Refernces

• 1、 -. "PHTHALAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS". Page/Page column 15. . Retrieved 2008/06/13.