(+/-)-2-(METHYLAMINO)PROPIOPHENONE HYDROCHLORIDE

Base Information

• Chemical Name: (+/-)-2-(METHYLAMINO)PROPIOPHENONE HYDROCHLORIDE
• CAS No.: 49656-78-2
• Molecular Formula: C10H14ClNO
• Molecular Weight: 199.68
• Hs Code.: 2922399090
• Mol file: 49656-78-2.mol

Synonyms:1-Propanone,2-(methylamino)-1-phenyl-, hydrochloride (9CI);1-Propanone,2-(methylamino)-1-phenyl-, hydrochloride, (?à)-;dl-Ephedrone hydrochloride;

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of (+/-)-2-(METHYLAMINO)PROPIOPHENONE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.0169mmHg at 25°C
• Melting Point: 179-184°C
• Boiling Point: 318.7 °C at 760 mmHg
• Flash Point: 158.6 °C
• PSA: 29.10000
• Density: 0.984 g/cm³
• LogP: 2.67010
• Storage Temp.: 2-8°C

Purity/Quality:

Safty Information:

• Pictogram(s): F；T；Xi
• Hazard Codes: F,T,Xi
• Statements: 11-23/24/25-39/23/24/25-36/37/38
• Safety Statements: 7-16-36/37-45-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Description: Methcathinone is a psychoactive cathinone. It is a β-ketone analog of methamphetamine and has comparable effects on monoamine uptake. Methcathinone is regulated as a Schedule I controlled substance in the United States. This product is intended for forensic and research applications only.
• Uses: Controlled substance (stimulant).

Technology Process of (+/-)-2-(METHYLAMINO)PROPIOPHENONE HYDROCHLORIDE

There total 4 articles about (+/-)-2-(METHYLAMINO)PROPIOPHENONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-1-phenylpropan-1-one (6084-17-9) + methylamine (74-89-5) → 2-methylamino-1-phenyl-1-propanone hydrochloride (49656-78-2)

Guidance literature:

2-chloro-1-phenylpropan-1-one; methylamine; With potassium carbonate; In benzene; at 5 - 30 ℃; for 10h; under 375.038 Torr; Inert atmosphere; Sealed tube;

With hydrogenchloride; In water; at 5 ℃; pH=1 - 2; Temperature; Solvent;

Reference yield:

benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 2-methylamino-1-phenyl-1-propanone hydrochloride (49656-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 4 h / 0 - 30 °C / Inert atmosphere

2.1: potassium carbonate / benzene / 10 h / 5 - 30 °C / 375.04 Torr / Inert atmosphere; Sealed tube

2.2: 5 °C / pH 1 - 2

With aluminum (III) chloride; potassium carbonate; In benzene; 1.1: |Friedel-Crafts Acylation;

Reference yield:

2-bromo-1-phenyl-1-propanone (2114-00-3) + methylamine (74-89-5) → 2-methylamino-1-phenyl-1-propanone hydrochloride (49656-78-2)

Guidance literature:

2-bromo-1-phenyl-1-propanone; methylamine; In tetrahydrofuran;

With hydrogenchloride; In diethyl ether; water;

DOI:10.1002/rcm.6383

upstream raw materials:

2-bromo-1-phenyl-1-propanone

methylamine

2-chloro-1-phenylpropan-1-one

benzene

Downstream raw materials:

1,3-dihydro-1,5-dimethyl-4-phenyl-2H-imidazole-2-thione

N-(3,4-dimethyl-5-phenyl-3H-oxazol-2-ylidene)-acetamide

N-(3,4-dimethyl-5-phenyl-3H-oxazol-2-ylidene)-benzamide

N-(3,4-dimethyl-5-phenyl-3H-oxazol-2-ylidene)-propionamide

Refernces

• 1、 -. "Preparation methods for ephedrine or pseudoephedrine and for ephedrine or pseudoephedrine intermediate". Paragraph 0100; 0101; 0102; 0103; 0104; 0105; 0106-0113. . Retrieved 2017/04/14.