3-[4-(TRIFLUOROMETHYL)PHENYL]-3-PYRROLIDINOL

Base Information

• Chemical Name: 3-[4-(TRIFLUOROMETHYL)PHENYL]-3-PYRROLIDINOL
• CAS No.: 1000198-74-2
• Molecular Formula: C₁₁H₁₂F₃NO
• Molecular Weight: 231.218
• Mol file: 1000198-74-2.mol

Synonyms:rac-3-(4-Trifluoromethyl-phenyl)-pyrrolidin-3-ol

Chemical Property of 3-[4-(TRIFLUOROMETHYL)PHENYL]-3-PYRROLIDINOL

Chemical Property:

• Boiling Point: 262.5±40.0 °C(Predicted)
• PKA: 13.65±0.20(Predicted)
• Density: 1.299±0.06 g/cm3(Predicted)

Purity/Quality:

95%-98% ^*data from raw suppliers

3-[4-(Trifluoromethyl)phenyl]-3-pyrrolidinolHCl 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-(TRIFLUOROMETHYL)PHENYL]-3-PYRROLIDINOL

There total 1 articles about 3-[4-(TRIFLUOROMETHYL)PHENYL]-3-PYRROLIDINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

rac-3-Hydroxy-3-(4-trifluoromethyl-phenyl)-pyrrolidine-1-carboxylic acid ethyl ester (1000198-73-1) → rac-3-(4-Trifluoromethyl-phenyl)-pyrrolidin-3-ol (1000198-74-2)

Guidance literature:

rac-3-Hydroxy-3-(4-trifluoromethyl-phenyl)-pyrrolidine-1-carboxylic acid ethyl ester; With potassium hydroxide; In 1,4-dioxane; butan-1-ol; for 2h; Heating / reflux;

With water;

Reference yield: 18.0%

rac-3-(4-Trifluoromethyl-phenyl)-pyrrolidin-3-ol (1000198-74-2) → 3-(4-Trifluoromethyl-phenyl)-2,5-dihydro-1H-pyrrole (1000198-75-3)

Guidance literature:

rac-3-(4-Trifluoromethyl-phenyl)-pyrrolidin-3-ol; With trifluoroacetic acid; In dichloromethane; for 120h; Heating / reflux;

With sodium hydroxide; In water; ethyl acetate; pH=9 - 10;

upstream raw materials:

rac-3-Hydroxy-3-(4-trifluoromethyl-phenyl)-pyrrolidine-1-carboxylic acid ethyl ester

Downstream raw materials:

3-(4-Trifluoromethyl-phenyl)-2,5-dihydro-1H-pyrrole

Refernces