5-(2-CHLOROPHENYL)-1H-TETRAZOLE

Base Information

• Chemical Name: 5-(2-CHLOROPHENYL)-1H-TETRAZOLE
• CAS No.: 50907-46-5
• Molecular Formula: C7H5 Cl N4
• Molecular Weight: 180.596
• Mol file: 50907-46-5.mol

Synonyms:1H-Tetrazole,5-(2-chlorophenyl)- (9CI); Tetrazole, 5-(o-chlorophenyl)- (6CI,7CI);5-(2-Chlorophenyl)-1H-tetrazole; 5-(2-Chlorophenyl)-2H-tetrazole;5-(2-Chlorophenyl)tetrazole; 5-(o-Chlorophenyl)tetrazole

Chemical Property of 5-(2-CHLOROPHENYL)-1H-TETRAZOLE

Chemical Property:

• Vapor Pressure: 1.36E-05mmHg at 25°C
• Melting Point: 179-180°C
• Boiling Point: 367.5°Cat760mmHg
• PKA: 3.78±0.10(Predicted)
• Flash Point: 207.6°C
• PSA: 54.46000
• Density: 1.448g/cm³
• LogP: 1.52010
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

5-(2-Chlorophenyl)-1H-tetrazole ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-(2-CHLOROPHENYL)-1H-TETRAZOLE is a useful research chemical.

Technology Process of 5-(2-CHLOROPHENYL)-1H-TETRAZOLE

There total 17 articles about 5-(2-CHLOROPHENYL)-1H-TETRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Chlorobenzonitrile (873-32-5) → 5-(2-chlorophenyl)-1H-tetrazole (50907-46-5)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 120 ℃; for 4h;

DOI:10.14233/ajchem.2017.20337

Reference yield: 92.0%

2-chloro-benzaldehyde (89-98-5) → 5-(2-chlorophenyl)-1H-tetrazole (50907-46-5)

Guidance literature:

With sodium azide; [((CH₃)3C)2Sn(OH)(H₂O)]2⁽²⁺⁾*2(OSO₂CF₃)^(1-)=[((CH₃)3C)2Sn(OH)(OSO₂CF₃)(H₂O)]2; hydroxylamine hydrochloride; In water; at 85 ℃; for 1h; Green chemistry;

DOI:10.1002/aoc.5132

Reference yield: 90.0%

C7H6ClN → 5-(2-chlorophenyl)-1H-tetrazole (50907-46-5)

Guidance literature:

With Nano TiO₂/SO₄^2-; for 5h; Green chemistry;

DOI:10.1016/j.crci.2013.11.002

upstream raw materials:

2-Chlorobenzonitrile

5-(2-chloro-phenyl)-tetrazol-1-ylamine

formic acid hydrazide

2-chlorobenzamide

Downstream raw materials:

N-[1-[5-(2-Chloro-phenyl)-tetrazol-1-yl]-1-phenyl-meth-(Z)-ylidene]-N'-(4-nitro-phenyl)-hydrazine

N-[1-[5-(2-Chloro-phenyl)-tetrazol-2-yl]-1-phenyl-meth-(Z)-ylidene]-N'-(4-nitro-phenyl)-hydrazine

5-(2-chlorophenyl)-1-methyl-1H-tetrazole

5-(2′-chlorophenyl)-2-methyltetrazole

Refernces

• 1、 Moradi, Parisa,Hajjami, Maryam. "Magnetization of biochar nanoparticles as a novel support for fabrication of organo nickel as a selective, reusable and magnetic nanocatalyst in organic reactions". . p. 2981 - 2994. Retrieved 2021/02/26.
• 2、 Ashraf, Muhammad Aqeel,Liu, Zhenling,Li, Cheng,Zhang, Dangquan. "Fe3O4@L-lysine-Pd(0) organic–inorganic hybrid: As a novel heterogeneous magnetic nanocatalyst for chemo and homoselective [2 + 3] cycloaddition synthesis of 5-substituted 1H-tetrazoles". . . Retrieved 2020/12/23.