Midazolam

Base Information

• Chemical Name: Midazolam
• CAS No.: 59467-64-0
• Molecular Formula: C16H15ClFN3
• Molecular Weight: 303.767
• Mol file: 59467-64-0.mol

Synonyms:1H-1,4-Benzodiazepine-2-methanamine,7-chloro-5-(2-fluorophenyl)-2,3-dihydro-;1-[7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]methanamine;

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Chemical Property of Midazolam

Chemical Property:

• Vapor Pressure: 5.21E-10mmHg at 25°C
• Refractive Index: 1.67
• Boiling Point: 443.9 °C at 760 mmHg
• PKA: 9.51±0.29(Predicted)
• Flash Point: 222.3 °C
• PSA: 30.18000
• Density: 1.362 g/cm³
• LogP: 3.75980

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An Intermediate for the synthesis of Midazolam

Technology Process of Midazolam

There total 5 articles about Midazolam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2-(1-nitromethylene)-2H-1,4-benzodiazepine 4-oxide → (7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methanamine (59467-64-0)

Guidance literature:

aluminum nickel; In tetrahydrofuran; methanol;

Reference yield:

C16H15ClFN3*C4H4O4 → (7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methanamine (59467-64-0)

Guidance literature:

With water; sodium hydroxide; In dichloromethane; pH=8 - 9;

Reference yield:

2-amino-5-chloro-2'-fluorobenzophenone (784-38-3) + 1,3-Diamino-2-hydroxypropane (616-29-5) → (7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methanamine (59467-64-0)

Guidance literature:

With hydrogen bromide; titanium tetrachloride; at 20 ℃; for 9h; Large scale;

upstream raw materials:

2-amino-5-chloro-2'-fluorobenzophenone

1,3-Diamino-2-hydroxypropane

epichlorohydrin

Downstream raw materials:

N-[7-chloro-5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-2,2,2-trifluoro-acetamide

N-[7-chloro-5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-acetamide

8-chloro-6-(2-fluoro-phenyl)-2,3,3a,4-tetrahydro-benzo[f]imidazo[1,5-a][1,4]diazepin-1-one

4-acetoxymidazolam

Refernces

• 1、 -. "A nitrogen-containing seven-membered ring derivatives of industrial production method". Paragraph 0084-0088. . Retrieved 2016/12/01.