3-Bromobenzyl chloride

Base Information

• Chemical Name: 3-Bromobenzyl chloride
• CAS No.: 932-77-4
• Molecular Formula: C7H6 Br Cl
• Molecular Weight: 205.482
• Hs Code.: 2903999090
• Mol file: 932-77-4.mol

Synonyms:Toluene,m-bromo-a-chloro- (7CI,8CI); 3-Bromobenzylchloride; m-Bromo-a-chlorotoluene; m-Bromobenzyl chloride

Chemical Property of 3-Bromobenzyl chloride

Chemical Property:

• Appearance/Colour: clear colorless to light yellow liquid
• Vapor Pressure: 0.0448mmHg at 25°C
• Melting Point: 32.5oC
• Refractive Index: n20/D 1.583(lit.)
• Boiling Point: 116-118 ºC (17 mmHg)
• Flash Point: 113 ºC
• PSA: 0.00000
• Density: 1.608
• LogP: 3.18790
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromobenzyl Chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromobenzyl chloride

There total 7 articles about 3-Bromobenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(3-Bromophenyl)methanol (15852-73-0) → 3-bromobenzyl chloride (932-77-4)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; benzenesulfonyl chloride; In 1,2-dichloro-ethane; at 80 ℃; for 1.5h;

DOI:10.1080/00397911.2018.1482498

Reference yield:

sulfuryl dichloride (7791-25-5) + meta-bromotoluene (591-17-3) + dibenzoyl peroxide (94-36-0) → meta-bromobenzyl bromide (823-78-9) + 1-Chloro-3-chloromethyl-benzene (620-20-2,130468-19-8) + 3-bromobenzyl chloride (932-77-4)

Guidance literature:

at 110 ℃;

DOI:10.1021/ja01150a509

Reference yield:

(3-Bromophenyl)methanol (15852-73-0) → meta-bromobenzyl bromide (823-78-9) + 3-bromobenzyl chloride (932-77-4)

Guidance literature:

With 1,3,5-trichloro-2,4,6-triazine; sodium bromide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.416667h; chemoselective reaction;

DOI:10.1055/s-0028-1083247

upstream raw materials:

meta-bromotoluene

(3-Bromophenyl)methanol

sulfuryl dichloride

dibenzoyl peroxide

Downstream raw materials:

4-(m-Bromophenyl)-2-butanone

3-[2-(3-Bromo-phenyl)-ethyl]-pyridine-2-carboxylic acid tert-butylamide

(2-(3-bromobenzyl)allyl)trimethylsilane

(E)-1-(3-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride

Refernces

• 1、 Chen, Jia,Lin, Jin-Hong,Xiao, Ji-Chang. "Halogenation through Deoxygenation of Alcohols and Aldehydes". supporting information. p. 3061 - 3064. Retrieved 2018/05/28.
• 2、 Nieddu, Giammario,De Luca, Lidia,Giacomelli, Giampaolo. "A chemoselective, easy bromination of (hydroxymethyl)phenols". experimental part. p. 3937 - 3940. Retrieved 2009/05/26.