2-Methoxycarbonylmethoxyimino-4-chloro-3-oxobutyric acid

Base Information

• Chemical Name: 2-Methoxycarbonylmethoxyimino-4-chloro-3-oxobutyric acid
• CAS No.: 84080-70-6
• Molecular Formula: C7H8ClNO6
• Molecular Weight: 237.597
• Hs Code.: 2925290090
• Mol file: 84080-70-6.mol

Synonyms:Butanoicacid, 4-chloro-2-[(2-methoxy-2-oxoethoxy)imino]-3-oxo-, (Z)-;butanoic acid, 4-chloro-2-[(2-methoxy-2-oxoethoxy)imino]-3-oxo-, (2E)-;

Chemical Property of 2-Methoxycarbonylmethoxyimino-4-chloro-3-oxobutyric acid

Chemical Property:

• Vapor Pressure: 2.58E-06mmHg at 25°C
• Refractive Index: 1.515
• Boiling Point: 364.756 °C at 760 mmHg
• PKA: 1.68±0.12(Predicted)
• Flash Point: 174.398 °C
• PSA: 102.26000
• Density: 1.479 g/cm³
• LogP: -0.57550
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Dichloromethane

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-2-((2-methoxy-2-oxoethoxy)-imino)-3-oxobutanoic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (Z)-4-Chloro-2-((2-methoxy-2-oxoethoxy)imino)-3-oxobutanoic Acid is an intermediate for the synthesis of Cefixime-13C,15N2 (C242802), which is labelled Cefixime (C242800). Orally active, third generation cephalosporin antibiotic.

Technology Process of 2-Methoxycarbonylmethoxyimino-4-chloro-3-oxobutyric acid

There total 1 articles about 2-Methoxycarbonylmethoxyimino-4-chloro-3-oxobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.5%

tert-butyl (Z)-2-((2-methoxy-2-oxoethoxy)imino)-3-oxobutanoate (84080-68-2,268544-50-9) → 4-Chloro-2-methoxycarbonylmethoxyimino-3-oxobutyric acid (84080-70-6)

Guidance literature:

With sulfuryl dichloride; acetic acid; at 58 - 60 ℃; for 1h;

DOI:10.1016/S0014-827X(99)00118-4

Reference yield: 93.8%

diazodiphenylmethane (908093-98-1) + 4-Chloro-2-methoxycarbonylmethoxyimino-3-oxobutyric acid (84080-70-6) → Diphenylmethyl 4-chloro-2-methoxycarbonylmethoxyimino-3-oxobutyrate

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/S0014-827X(99)00118-4

Reference yield:

thiourea (17356-08-0) + 4-Chloro-2-methoxycarbonylmethoxyimino-3-oxobutyric acid (84080-70-6) → 2-(2-aminothiazol-4-yl)-2-[(Z)-methoxycarbonylmethoxyimino]acetic acid (80544-17-8)

Guidance literature:

thiourea; 4-Chloro-2-methoxycarbonylmethoxyimino-3-oxobutyric acid; With sodium acetate; In water; at 12 - 30 ℃; for 3h;

With hydrogenchloride; In water; at 0 - 10 ℃; for 1h; pH=3;

upstream raw materials:

tert-butyl (Z)-2-((2-methoxy-2-oxoethoxy)imino)-3-oxobutanoate

Downstream raw materials:

2-(2-aminothiazol-4-yl)-2-[(Z)-methoxycarbonylmethoxyimino]acetic acid

Refernces