Enrofloxacin hydrochloride

Base Information

• Chemical Name: Enrofloxacin hydrochloride
• CAS No.: 112732-17-9
• Molecular Formula: C₁₉H₂₂FN₃O₃*ClH
• Molecular Weight: 395.861
• Mol file: 112732-17-9.mol

Synonyms:3-Quinolinecarboxylicacid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-,hydrochloride (9CI);Enrofloxacin hydrochloride;

Chemical Property of Enrofloxacin hydrochloride

Chemical Property:

• Vapor Pressure: 2.57E-14mmHg at 25°C
• Boiling Point: 560.5oC at 760mmHg
• Flash Point: 292.8oC
• PSA: 65.78000
• Density: 1.385g/cm3
• LogP: 3.12050
• Storage Temp.: 0-6°C
• Solubility.: Methanol (Slightly, Heated), Water (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

EnrofloxacinHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Enrofloxacin Hydrochloride is a fluorinated quinolone antibacterial.

Technology Process of Enrofloxacin hydrochloride

There total 1 articles about Enrofloxacin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-5-fluorobenzoyl chloride (86393-34-2) → Enrofloxacin hydrochloride (93106-59-3,112732-17-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 62 percent / pyridine / dioxane / 1.) 2 h, room temperature, 2.) 1 h, 70 - 80 deg C_.

2: 85 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C

3: 92 percent / conc. H₂SO₄ / H₂O; acetic acid / 1.5 h / Heating

4: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C

5: conc. HCl / H₂O / Heating

With pyridine; hydrogenchloride; sulfuric acid; potassium carbonate; In 1,4-dioxane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

2,4-dichloro-5-fluorobenzoyl chloride

Refernces