1-Benzyl-4-(4-methoxyphenyl)tetrahydropyridine

Base Information

• Chemical Name: 1-Benzyl-4-(4-methoxyphenyl)tetrahydropyridine
• CAS No.: 13314-69-7
• Molecular Formula: C19H21 N O
• Molecular Weight: 279.382
• Hs Code.: 2933399090
• Mol file: 13314-69-7.mol

Synonyms:Pyridine,1-benzyl-1,2,3,6-tetrahydro-4-(p-methoxyphenyl)- (7CI,8CI)

Chemical Property of 1-Benzyl-4-(4-methoxyphenyl)tetrahydropyridine

Chemical Property:

• PSA: 12.47000
• LogP: 3.92240

Purity/Quality:

98%min ^*data from raw suppliers

1-benzyl-4-(4-methoxyphenyl)-1,2,3,6-tetrahydropyridine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzyl-4-(4-methoxyphenyl)tetrahydropyridine

There total 14 articles about 1-Benzyl-4-(4-methoxyphenyl)tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-bromo-4-methoxy-benzene (104-92-7) + 1-phenylmethyl-4-piperidone (3612-20-2) → 1-benzyl-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine (13314-69-7)

Guidance literature:

1-phenylmethyl-4-piperidone; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; toluene-4-sulfonic acid hydrazide; lithium tert-butoxide; XPhos; In 1,4-dioxane; for 0.0166667h; Inert atmosphere;

1-bromo-4-methoxy-benzene; In 1,4-dioxane; at 110 ℃; Inert atmosphere;

DOI:10.1002/chem.200800390

Reference yield: 99.0%

1-phenylmethyl-4-piperidone (3612-20-2) + 4-chloromethoxybenzene (623-12-1) → 1-benzyl-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine (13314-69-7)

Guidance literature:

1-phenylmethyl-4-piperidone; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; toluene-4-sulfonic acid hydrazide; lithium tert-butoxide; XPhos; In 1,4-dioxane; for 0.0166667h; Inert atmosphere;

4-chloromethoxybenzene; In 1,4-dioxane; at 110 ℃; for 6h; Inert atmosphere;

DOI:10.1002/chem.200800390

Reference yield: 88.0%

1-benzyl-4-(4-methoxy-phenyl)-piperidin-4-ol (6717-00-6) → 1-benzyl-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine (13314-69-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

upstream raw materials:

1-benzyl-4-(4-methoxy-phenyl)-piperidin-4-ol

1-phenylmethyl-4-piperidone

4-methoxyphenyl magnesium bromide

1-benzyl-4-(benzyldimethylsilanyl)-1,2,3,6-tetrahydro-pyridine hydrochloride

Downstream raw materials:

(±)-(3,4-trans)-4-(4-hydroxyphenyl)piperidin-3-ol

(3R,4S,5S)-4-(4-Hydroxy-phenyl)-piperidine-3,5-diol

RS)-1-benzyl-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridin-3-ol

(RS)-1-benzyl-3-ethoxy-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine

Refernces

• 1、 Arnatt, Christopher K.,Zaidi, Saheem A.,Zhang, Zhu,Li, Guo,Richardson, Amanda C.,Ware, Joy L.,Zhang, Yan. "Design, syntheses, and characterization of pharmacophore based chemokine receptor CCR5 antagonists as anti prostate cancer agents". . p. 647 - 658. Retrieved 2013.
• 2、 -. "Selective NR2B Antagonists". Paragraph 0443. . Retrieved 2015/07/15.